{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:00Z","timestamp":1785214800532,"version":"3.55.0"},"reference-count":87,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Endurance exercise\u2010induced fatigue is closely associated with disordered lactic acid metabolism. As a natural long\u2010chain alcohol, octacosanol (Octa) exhibits anti\u2010fatigue effects, while its detailed mechanism remains unclear. This study investigated the effect of Octa on lactic acid metabolism in the gastrocnemius muscle of mice subjected to exhaustive exercise and explored the potential gut\u2013muscle axis mechanisms involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We found that Octa supplementation significantly enhanced endurance performance, reduced lactic acid accumulation in plasma and muscle, and upregulated the lactic acid transporter MCT1. Octa reshaped the gut microbiota structure, increasing the abundance of beneficial bacteria and the production of short\u2010chain fatty acids. Consequently, it suppressed the LPS\/TLR4\/NF\u2010\u03baB inflammatory pathway and ameliorated oxidative stress by activating NRF2\/ARE signaling. These changes were accompanied by enhanced mitochondrial biogenesis and function, as evidenced by increased PGC\u20101\u03b1 expression, mtDNA copy number, and expression of key enzyme in the oxidative phosphorylation pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our findings demonstrate that Octa improves lactic acid metabolism and attenuates exercise\u2010induced fatigue through a gut microbiota\u2010regulated mechanism involving the suppression of inflammation and oxidative stress, and the enhancement of mitochondrial function via the NRF2\/PGC\u20101\u03b1 pathway. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70922","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:23:09Z","timestamp":1785212589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Octacosanol improves lactic acid clearance during exhaustive exercise via gut microbiota remodeling and improved mitochondrial function"],"prefix":"10.1002","author":[{"given":"Yin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Huzhou Central Hospital Fifth School of Clinical Medicine of Zhejiang Chinese Medical University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety School of Food Science and Biotechnology, Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Huzhou Central Hospital Fifth School of Clinical Medicine of Zhejiang Chinese Medical University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety School of Food Science and Biotechnology, Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Jia","sequence":"additional","affiliation":[{"name":"Food Safety Key Laboratory of Zhejiang Province, National Experimental Teaching Demonstration Center for Food Engineering and Quality and Safety School of Food Science and Biotechnology, Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiudong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Physical Education Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Accounting, Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Chen","sequence":"additional","affiliation":[{"name":"Huzhou Shengtao Biotechnology LLC.  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