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This work investigated ultrasound\u2010assisted extraction (UAE) coupled with a recirculation system as a strategy to improve their recovery. The effects of pump speed (909\u20131864\u2009min\n \u22121<\/jats:sup>\n ) and ultrasound power (80\u2013360\u2009W) on phenolic content, monomeric anthocyanins and antioxidant capacity were assessed. Extractions were performed using ethanol\u2013water solution (500\u2009mL\u2009L\n \u22121<\/jats:sup>\n ethanol) at a solid\u2010liquid ratio of 50\u2009g\u2009L\n \u22121<\/jats:sup>\n and kinetic assays established 90\u2009min as the optimal extraction time.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Total phenolic content varied from 8.55\u2009\u00b1\u20090.15 to 14.04\u2009\u00b1\u20090.14\u2009g gallic acid equivalent kg\n \u22121<\/jats:sup>\n . Antioxidant capacity varied between 10.11\u201318.31\u2009g Trolox kg\n \u22121<\/jats:sup>\n [2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid)] and 7.32\u201312.90\u2009g Trolox kg\n \u22121<\/jats:sup>\n (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl), whereas monomeric anthocyanins varied from 0.149\u2009\u00b1\u20090.006 to 0.236\u2009\u00b1\u20090.002\u2009g malvidin\u20103\u2010\n O<\/jats:italic>\n \u2010glucoside kg\n \u22121<\/jats:sup>\n . Ultrasound power significantly enhanced extraction efficiency as a result of intensified cavitation, whereas pump speed showed a synergistic effect at high power. Optimal conditions were established at 1725\u2009min\n \u22121<\/jats:sup>\n and 320\u2009W. The optimized system achieved greater extraction yields compared to conventional extraction, along with improved antioxidant capacity. Major phenolic compounds identified included gallic, vanillic and protocatechuic acids, catechin, epicatechin,\n p<\/jats:italic>\n \u2010coumaric acid, quercetin, and ellagic acid, with malvidin\u20103\u2010\n O<\/jats:italic>\n \u2010glucoside as the predominant anthocyanin.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n UAE combined with recirculation proved to be a suitable process with scale\u2010up potential, enhancing extraction kinetics and bioactive compound recovery, supporting its application in grape pomace valorization. \u00a9 2026 The Author(s).\n Journal of the Science of Food and Agriculture<\/jats:italic>\n published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.70925","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:11:55Z","timestamp":1785413515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010assisted recirculation extraction as an innovative approach for obtaining bioactive compounds from grape pomace"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-1064","authenticated-orcid":false,"given":"Jailton Ribeiro Dos Santos","family":"Junior","sequence":"first","affiliation":[{"name":"Graduate Program in Food Science, Institute of Chemistry Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5405-3763","authenticated-orcid":false,"given":"Luiz Carlos","family":"Corr\u00eaa\u2010Filho","sequence":"additional","affiliation":[{"name":"Graduate Program in Food Science and Technology Federal Rural University of Rio de Janeiro Serop\u00e9dica Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayvison Mendes","family":"Moreira","sequence":"additional","affiliation":[{"name":"Graduate Program in Food Science, Institute of Chemistry Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-2760","authenticated-orcid":false,"given":"Renata Valeriano","family":"Tonon","sequence":"additional","affiliation":[{"name":"Embrapa Food Technology Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-0381","authenticated-orcid":false,"given":"Lourdes Maria Correa","family":"Cabral","sequence":"additional","affiliation":[{"name":"Embrapa Food Technology Rio de Janeiro 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