{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:02:30Z","timestamp":1785243750885,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Flavonoids naturally coexisting with lutein in marigold (\n                      <jats:italic>Tagetes erecta L.<\/jats:italic>\n                      ) extracts have been suggested to influence carotenoid bioavailability; however, their coordinated roles in intestinal lutein absorption remain insufficiently understood. This study systematically explored the synergistic effects of six major marigold flavonoids on lutein absorption via a multilevel strategy integrating emulsion behavior, intestinal epithelial transport and gut microbiota modulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      , flavonoids stabilized lutein\u2010containing mixed emulsion, reduced particle size, increased \u03b6\u2010potential and enhanced bioaccessibility. In Caco\u20102 cells, they promoted lutein uptake and trans\u2010epithelial transport, upregulated key transporters (SR\u2010BI, CD36, NPC1L1) and reinforced tight junction integrity.\n                      <jats:italic>In vivo<\/jats:italic>\n                      , their co\u2010administration increased lutein accumulation in eyes, liver and intestinal tissues, enhanced carotenoid cleavage enzyme activities, and reshaped gut microbiota and short\u2010chain fatty acid production.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Marigold flavonoids facilitate intestinal lutein absorption via multiple pathways, improving the\n                      <jats:italic>in vivo<\/jats:italic>\n                      bioavailability of lutein. This study clarifies the synergistic interaction between marigold flavonoids and lutein, providing a theoretical basis for the rational application of marigold\u2010derived flavonoids and carotenoids in functional food development. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70929","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:14:30Z","timestamp":1785240870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Marigold flavonoids coordinate emulsion stabilization, epithelial transport and gut microbiota modulation to enhance intestinal lutein absorption"],"prefix":"10.1002","author":[{"given":"Sitong","family":"Wang","sequence":"first","affiliation":[{"name":"College of Food Science and Technology Hebei Agricultural University  Baoding 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