{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:29:24Z","timestamp":1787725764502,"version":"build-2784847793"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Bovine blood is a protein\u2010rich by\u2010product of the meat industry, yet its potential as a source of bioactive peptides remains underexplored. Pancreatic lipase (PL) is a key enzyme in lipid digestion, and its inhibition represents a promising strategy for managing obesity. This study aimed to identify and characterize novel PL inhibitory peptides derived from bovine blood and to elucidate their binding mechanisms through molecular docking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Bovine blood proteins were hydrolyzed using a multi\u2010enzyme system, 592 peptides were identified using liquid chromatography coupled with tandem mass spectrometry. Through virtual screening based on docking energy, toxicity prediction, and PeptideRanker scores, the peptides TQRFF and FTPVF were prioritized for analysis. Subsequently, molecular docking analysis revealed that TQRFF stabilized the PL complex through hydrogen bonding as well as cation\u2013\u03c0, \u03c0\u2013\u03c0, \u03c0\u2013alkyl and alkyl interactions. Meanwhile, FTPVF formed salt bridges and demonstrated hydrogen bonding, cation\u2013\u03c0 interactions, \u03c0\u2013\u03c0 interactions and alkyl interactions. Molecular dynamics simulations revealed greater conformational stability in the FTPVF\u2013PL complex, whereas TQRFF was found to induce protein compaction and form stronger hydrogen bonds. Finally, in\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiments conducted after synthesizing these two key peptides, both TQRFF and FTPVF exhibited potent\n                      <jats:italic>in vitro<\/jats:italic>\n                      PL inhibitory activity, with half maximal inhibitory concentration (IC\n                      <jats:sub>50<\/jats:sub>\n                      ) values of 260.02\u2009\u00b1\u200917.01\u2009\u03bcg\u2009mL\n                      <jats:sup>\u20131<\/jats:sup>\n                      and 760.04\u2009\u00b1\u200959.03\u2009\u03bcg\u2009mL\n                      <jats:sup>\u20131<\/jats:sup>\n                      , respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The bovine blood\u2010derived peptides TQRFF and FTPVF are novel PL inhibitors with promising anti\u2010obesity potential. Their binding modes involve key interactions with the active site residues, supporting further development as functional food ingredients. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70930","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:16:46Z","timestamp":1785241006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification, characterization and molecular docking study of pancreatic lipase inhibitory peptides from bovine blood"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-7960","authenticated-orcid":false,"given":"Haibin","family":"Ren","sequence":"first","affiliation":[{"name":"College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Hebei Province Key Laboratory of Sustainable Utilization and Development of Forest Food Resources Beijing Forestry University  Beijing China"},{"name":"Grain Research and Development Center, Nutrition &amp; Health Research Institute COFCO Corporation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Hebei Province Key Laboratory of Sustainable Utilization and Development of Forest Food Resources Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Hebei Province Key Laboratory of Sustainable Utilization and Development of Forest Food Resources Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Hebei Province Key Laboratory of Sustainable Utilization and Development of Forest Food Resources Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Hebei Province Key Laboratory of Sustainable Utilization and Development of Forest Food Resources Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-2792","authenticated-orcid":false,"given":"Difeng","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Hebei Province Key Laboratory of Sustainable Utilization and Development of Forest Food Resources Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"The American Board of Obesity Medicine a Pathway to provision of competent obesity medicine care","volume":"54","author":"Johnson\u2010Rabbett B","year":"2025","journal-title":"Endocrinol Metab Clin N Am"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2508296"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2025.2513106"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/s11695-025-07869-7","article-title":"The Venice declaration: obesity as a disease\u2010a call to action for diagnosis, multimodal treatment, and policy change","volume":"35","author":"Luca M","year":"2025","journal-title":"Obes Surg"},{"key":"e_1_2_7_6_1","first-page":"897","article-title":"Inhibitors of pancreatic lipase: STATE of the art and clinical perspectives","volume":"13","author":"Lunagariya NA","year":"2014","journal-title":"EXCLI J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4155\/fmc-2018-0216","article-title":"Discovery of arginine\u2010containing tripeptides as a new class of pancreatic lipase inhibitors","volume":"11","author":"Stefanucci A","year":"2019","journal-title":"Future Med Chem"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"170577","DOI":"10.1016\/j.peptides.2021.170577","article-title":"Plant\u2010derived peptides improving lipid and glucose metabolism","volume":"142","author":"Nagaoka S","year":"2021","journal-title":"Peptides"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jff.2017.03.029","article-title":"The potential roles of pinto bean (Phaseolus vulgaris cv. 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