{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:15:25Z","timestamp":1789456525643,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22578001"],"award-info":[{"award-number":["22578001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Cacumen Platycladi (CP), the dried twigs and leaves of\n                      <jats:italic>Platycladus orientalis<\/jats:italic>\n                      , is a food\u2010related botanical with potential hair health\u2010promoting activity. However, the principal bioactive constituent responsible for its anti\u2010alopecia effect and the underlying mechanism remain unclear. This study aimed to identify the key anti\u2010alopecia constituent of CP and investigate its mechanism of action against androgenetic alopecia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Six major candidate compounds were identified from CP by fractionated extraction, gas chromatography\u2013mass spectrometry, liquid chromatography\u2013mass spectrometry, and network pharmacology analysis. Among them, amentoflavone showed the strongest anti\u2010alopecia activity. In a testosterone\u2010induced mouse model, amentoflavone increased mean hair length by 1.10\u2010fold and hair density by 1.33\u2010fold\n                      <jats:italic>versus<\/jats:italic>\n                      the model group, improved follicular morphology, reduced the proportion of vellus hair by 50.8%, and regulated serum hormone levels. Western blot analysis further showed that amentoflavone increased \u03b2\u2010catenin and cyclin D1 expression while decreasing GSK\u20103\u03b2 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Amentoflavone was identified as the principal anti\u2010alopecia constituent of CP. Its beneficial effect was associated with activation of the Wnt\/\u03b2\u2010catenin signaling pathway, suggesting that CP is a promising source of functional bioactive compounds for hair health\u2010related applications. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70961","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:57:55Z","timestamp":1789455475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Food\u2010related botanical\n                    <i>Cacumen Platycladi<\/i>\n                    alleviates androgenetic alopecia through activating the\n                    <scp>W<\/scp>\n                    nt\/\u03b2\u2010catenin pathway"],"prefix":"10.1002","author":[{"given":"Lei","family":"Gong","sequence":"first","affiliation":[{"name":"Key Laboratory of Ecological Engineering and Biotechnology of Anhui 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