{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:44:33Z","timestamp":1785908673501,"version":"3.56.0"},"reference-count":140,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), represents a significant global health challenge. Growing evidence indicates that\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                      , a promising next\u2010generation beneficial microorganism, could help alleviate metabolic disorders. Nevertheless, its strain\u2010specific effects and associated mechanisms require further investigation. Here, we investigated the potential effects of pasteurized\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                      AKK PROBIO in T2DM using\n                      <jats:italic>db\/db<\/jats:italic>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Our findings show that pasteurized AKK PROBIO supplementation was associated with lower fasting glucose levels, reduced inflammatory markers, and improved cholesterol balance in db\/db mice. Pasteurized AKK PROBIO administration was accompanied by changes in gut microbiota composition, including enrichment of bacterial taxa linked to short\u2010chain fatty acid (SCFA) production, and by increased GLP\u20101 levels and altered serum metabolites, including 9,9\u2032\u2010di\u2010\n                      <jats:italic>cis<\/jats:italic>\n                      \u2010\u03b6\u2010carotene and\n                      <jats:sc>l<\/jats:sc>\n                      \u2010arginine. These changes were paralleled by reduced hepatic expression of proteins related to the TLR4\/MyD88\/IKK\u03b1\/NF\u2010\u03baB and SREBP2\/HMGCR signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Taken together, our findings indicate that pasteurized AKK PROBIO ameliorates metabolic disorder and inflammation in\n                      <jats:italic>db\/db<\/jats:italic>\n                      mice, accompanied by changes in gut microbial ecology, serum metabolites, and hepatic inflammatory\/lipid metabolic signaling. This study supports pasteurized\n                      <jats:italic>A. muciniphila<\/jats:italic>\n                      AKK PROBIO as a postbiotic for further investigation in metabolic disorders. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70969","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:50:01Z","timestamp":1785905401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pasteurized\n                    <i>Akkermansia muciniphila<\/i>\n                    <scp>AKK PROBIO<\/scp>\n                    ameliorates inflammation and metabolic disorder in\n                    <i>db\/db<\/i>\n                    mice with alterations in gut microbiota and hepatic\n                    <scp>TLR4<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    and\n                    <scp>SREBP2<\/scp>\n                    \/\n                    <scp>HMGCR<\/scp>\n                    signaling"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6926-998X","authenticated-orcid":false,"given":"Mengling","family":"Chen","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangling","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin Agricultural University  Changchun 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