{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:10:21Z","timestamp":1790809821120,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n Polysaccharide\u2013protein (PSP) complexes derived from edible fungi are promising candidates against tumors, offering substantial efficacy with minimal side effects. This study aimed to isolate a PSP from the cultivated mycelia of the edible fungus\n Inonotus hispidus<\/jats:italic>\n and evaluate its antitumor potential.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Through activity\u2010guided fractionation, a highly active fraction, PSP\u20101, was attained and characterized as a PSP complex containing 644.8\u2009g\u2009kg\n \u22121<\/jats:sup>\n total sugar and 288.9\u2009g\u2009kg\n \u22121<\/jats:sup>\n protein, with an average molecular weight of 327\u2009kDa. The polysaccharide portion of PSP\u20101 was composed of glucose, mannose, galactose, and fucose at a molar ratio of 4.90:2.55:3.35:1.00, and the protein part was composed dominantly of glutamic acid, methionine, and aspartic acid.\n In vivo<\/jats:italic>\n , PSP\u20101 showed a significant tumor inhibition rate of 36.9\u2009\u00b1\u20092.3% at a low dose of 100\u2009mg\u2009kg\n \u22121<\/jats:sup>\n in a hepatocellular carcinoma model and doubled the antitumor efficacy of cyclophosphamide. In HepG2 cancer cell culture, PSP\u20101 significantly inhibited cell proliferation with an half\u2010maximal inhibitory concentration (IC\n 50<\/jats:sub>\n ) value of 87.9\u2009\u03bcg\u2009mL\n \u22121<\/jats:sup>\n . PSP\u20101 induced apoptosis via cell cycle arrest through a mitochondria\u2010mediated Caspase\u2010dependent pathway.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n The findings suggest that the\n I. hispidus<\/jats:italic>\n mycelium\u2010derived PSP complex is a promising component in functional foods to prevent the occurrence and inhibit the development of liver tumors, either alone or in combination with chemotherapy drugs. \u00a9 2026 Society of Chemical Industry.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.70970","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:20:30Z","timestamp":1786681230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Growth inhibition of hepatocellular carcinoma by the polysaccharide\u2013protein complex from\n \n Inonotus hispidus<\/i>\n <\/scp>\n mycelia and the mechanisms"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9221-407X","authenticated-orcid":false,"given":"Hongzhen","family":"Guo","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolin","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nodirali","family":"Normakhamatov","sequence":"additional","affiliation":[{"name":"Department of Scientific Research and Innovations Tashkent Pharmaceutical Institute Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41571-021-00573-2","article-title":"Immunotherapies for hepatocellular carcinoma","volume":"19","author":"Llovet JM","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi H","year":"2023","journal-title":"J Hepatol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.838179","article-title":"Polysaccharides as potential anti\u2010tumor biomascromolecules\u2010a review","volume":"9","author":"Guo R","year":"2022","journal-title":"Front Nutr"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132300","article-title":"Future prospect of polysaccharide as a potential therapy in hepatocellular carcinoma: a review","volume":"270","author":"Cai Y","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ijbiomac.2019.09.002","article-title":"Protective effects of polysaccharides on hepatic injury: a review","volume":"141","author":"Yuan Y","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126766","article-title":"Recent advances in natural polysaccharides against hepatocellular carcinoma: a review","volume":"253","author":"Wang D","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3897\/mycokeys.57.36376","article-title":"Sanghuangporus toxicodendri sp. nov. 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