{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:34:12Z","timestamp":1792017252006,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Postmenopausal osteoporosis (PMO), driven primarily by estrogen deficiency, is the most prevalent form of osteoporosis and a major global health burden. Estrogen deficiency disrupts gut microbial homeostasis, compromises intestinal barrier integrity and promotes inflammatory bone loss partly through dysregulation of the osteoprotegerin (OPG)\/receptor activator of nuclear factor\u2010\u03baB ligand (RANKL) axis. However, the safety concerns and poor adherence associated with long\u2010term pharmacotherapy underscore the need for safer nutritional strategies. Here, we evaluated the protective effects of 2\u2032\u2010fucosyllactose (2\u2032\u2010FL), a natural milk oligosaccharide, against PMO using chondroitin sulfate (CS) as a comparator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The results showed that 2\u2032\u2010FL restored the balance of the OPG\/RANKL axis, improved intestinal integrity and reduced inflammatory cytokine levels. Linear discriminant analysis effect size\u2010based analysis further indicated that 2\u2032\u2010FL may reshape the gut microbiota by promoting the enrichment of selected beneficial microbial taxa, including\n                      <jats:italic>Adlercreutzia<\/jats:italic>\n                      ,\n                      <jats:italic>Gordonibacter<\/jats:italic>\n                      and\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      , at the same time as reducing the relative abundance of\n                      <jats:italic>Ruminococcus<\/jats:italic>\n                      and\n                      <jats:italic>Prevotella<\/jats:italic>\n                      under estrogen\u2010deficient conditions. Moreover, 2\u2032\u2010FL exhibited comparable efficacy to CS in restoring bone homeostasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Collectively, these findings demonstrate that 2\u2032\u2010FL alleviates both bone loss and intestinal dysfunction under estrogen\u2010deficient conditions. 2\u2032\u2010FL improved bone microarchitecture, favourably modulated bone\u2010remodelling and intestinal barrier\u2010associated markers, reduced inflammation and concurrently altered gut microbial composition. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70980","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T01:49:59Z","timestamp":1786758599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["2\u2032\u2010\n                    <scp>Fucosyllactose<\/scp>\n                    attenuates estrogen\u2010deficiency\u2010associated bone loss and intestinal dysfunction in ovariectomized rats"],"prefix":"10.1002","author":[{"given":"Shengpeng","family":"Su","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"},{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusen","family":"Li","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Gou","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna","family":"Sun","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiruonan","family":"Shen","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"He","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-3306","authenticated-orcid":false,"given":"Wentao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julong","family":"Liu","sequence":"additional","affiliation":[{"name":"Mengniu Hi\u2010Tech Dairy Product Beijing Co., Ltd.  Beijing China"},{"name":"Inner Mongolia Mengniu Dairy Industry Co., Ltd.  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-022-00371-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-023-01058-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114523002362"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-023-1971-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-08120-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"ZhangJ LiangX TianX ZhaoM MuY YiHet al. Function Bifidobacterium improves oestrogen\u2010deficiency\u2010induced osteoporosis in mice by modulating intestinal immunity.15:1840\u20131851(2024).","DOI":"10.1039\/D3FO05212E"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-025-00424-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2314624"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118099"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.759843"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-023-00726-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081447"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330301"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-025-02094-x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2026.101352"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","unstructured":"P\u00e9rez\u2010EscalanteE Alatorre\u2010Santamar\u00edaS Casta\u00f1eda\u2010OvandoA Salazar\u2010PeredaV Bautista\u2010\u00c1vilaM Cruz\u2010GuerreroAEet al. 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