{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:21:13Z","timestamp":1787718073296,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370407"],"award-info":[{"award-number":["32370407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870316"],"award-info":[{"award-number":["31870316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Camellia oleifera<\/jats:italic>\n                      is a perennial tree widely cultivated in southern China. Its seed oil has traditionally been used as an edible oil and has been regarded in folk medicine as beneficial for gastrointestinal disorders and inflammatory conditions. Despite its long history of use, the scientific basis for the protective effects of\n                      <jats:italic>C. oleifera<\/jats:italic>\n                      oil (CO) against colitis remains unclear. This study aimed to evaluate the protective effects of CO in a dextran sulfate sodium (DSS)\u2010induced murine colitis model and elucidate whether modulation of the gut microbiota contributes to its anti\u2010colitis activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CO supplementation significantly alleviated DSS\u2010induced colitis, as evidenced by reduced body weight loss, alleviated colon shortening, improved intestinal barrier integrity, decreased inflammatory mediator levels, and a lower disease activity index. 16S rRNA sequencing showed that CO partially restored gut microbial homeostasis by increasing beneficial bacterial families (Eggerthellaceae, Corynebacteriaceae, Lactobacillaceae, and Muribaculaceae) while reducing potentially harmful taxa (Helicobacteraceae, Erysipelotrichales, Desulfovibrionaceae, and Tannerellaceae). CO treatment also modulated fecal short\u2010chain fatty acid (SCFA) profiles. Correlation analysis further suggested that improvements in colitis were associated with CO\u2010induced gut microbiota remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These findings demonstrate that CO exerts protective effects against DSS\u2010induced colitis, potentially through modulation of gut microbiota and SCFA metabolism. Although primarily consumed as an edible oil, CO exhibits health\u2010promoting properties, supporting its potential as a functional food for gastrointestinal health. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.70990","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:56:01Z","timestamp":1787716561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic effects of\n                    <scp>\n                      <i>Camellia oleifera<\/i>\n                    <\/scp>\n                    oil: modulation of gut microbiota and amelioration of dextran sulfate sodium\u2010induced colitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5923-0086","authenticated-orcid":false,"given":"Miaomiao","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Ecology and 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Ecology and Environment in Minority Areas (Minzu University of China), National Ethnic Affairs Commission  Beijing China"},{"name":"College of Life and Environmental Sciences Minzu University of China  Beijing China"},{"name":"Key Laboratory of Ethnomedicine (Minzu University of China), Ministry of Education  Beijing China"},{"name":"National Ethnic Affairs Commission Mass Spectrometry Imaging and Metabolomics (Minzu University of China)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congli","family":"Xu","sequence":"additional","affiliation":[{"name":"Baoshan Administration of Gaoligongshan National Nature Reserve  Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Long","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China), National Ethnic Affairs Commission  Beijing China"},{"name":"College of Life and Environmental Sciences Minzu University of China  Beijing China"},{"name":"Key Laboratory of Ethnomedicine (Minzu University of China), Ministry of Education  Beijing China"},{"name":"National Ethnic Affairs Commission Mass Spectrometry Imaging and Metabolomics (Minzu University of China)  Beijing China"},{"name":"Institute of National Security Studies, Minzu University of China  Beijing 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