{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:25:11Z","timestamp":1787567111179,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Black soldier fly larvae (BSFL) are critical to the circular economy, transforming hazardous organic wastes into sustainable agricultural feed. However, processing high\u2010bioburden substrates presents severe biosafety challenges. This review synthesizes recent advancements (2021\u20132026) regarding the multidimensional role of the BSFL gut bioreactor in waste sanitization and xenobiotic remediation. Pathogen neutralization is driven by a synergistic, tripartite defense system: host\u2010derived antimicrobial peptides (AMPs), biophysical lipid interactions (e.g., lauric acid), and microbiome\u2010mediated competitive exclusion. Concurrently, the gut microbiota deploys novel enzymatic pathways to actively degrade veterinary pharmaceuticals. Despite these sanitization capabilities, a profound biosafety paradox exists: while live, culturable vegetative pathogens and parent chemical antibiotics are eradicated, the intensive selective pressure within the gut environment facilitates horizontal gene transfer, leading to the amplification of antimicrobial resistance genes (ARGs). This study critically evaluates industrial interventions \u2013 including chemical pre\u2010treatments, abiotic stress modulation, and probiotic bioaugmentation \u2013 designed to engineer the bioreactor and mitigate these genetic and horizontal transfer risks. Finally, the study explores the downstream impacts of BSFL biomass as a functional substitute for antibiotic growth promoters in livestock, highlighting its prebiotic capacity to positively modulate animal microbiomes. Overcoming current methodological and regulatory limitations via multi\u2010omics will cement BSFL as a biosecure pillar of sustainable agriculture. \u00a9 2026 Society of Chemical Industry.<\/jats:p>","DOI":"10.1002\/jsfa.70995","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:46:45Z","timestamp":1787561205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The black soldier fly bioreactor: host\u2010microbiome synergy in pathogen neutralization, xenobiotic remediation, and downstream feed safety"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0547-6310","authenticated-orcid":false,"given":"Siarhei A","family":"Dabravolski","sequence":"first","affiliation":[{"name":"Department of Biotechnology Engineering Braude Academic College of Engineering  Karmiel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey A","family":"Vatlin","sequence":"additional","affiliation":[{"name":"Institute of Environmental Engineering of RUDN University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra Zh","family":"Erbaeva","sequence":"additional","affiliation":[{"name":"Institute of Environmental Engineering of RUDN University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Herrera","sequence":"additional","affiliation":[{"name":"Institute of Environmental Engineering of RUDN University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod V","family":"Pavshintsev","sequence":"additional","affiliation":[{"name":"Institute of Environmental Engineering of RUDN University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita A","family":"Mitkin","sequence":"additional","affiliation":[{"name":"Institute of Environmental Engineering of RUDN University  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.wasman.2023.03.023","article-title":"Isolated and identified pathogenic bacteria from black soldier fly larvae with \u201csoft rot\u201d reared in mass production facilities and its incidence characteristics","volume":"163","author":"She W","year":"2023","journal-title":"Waste Manag"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172823","article-title":"Black soldier fly\u2010based bioconversion of biosolids: microbial community dynamics and fate of antibiotic resistance genes","volume":"930","author":"Bohm K","year":"2024","journal-title":"Sci Total Environ"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.wasman.2025.01.019","article-title":"Microbial safety of black soldier fly larvae (Hermetia illucens) reared on food waste streams","volume":"194","author":"Alagappan S","year":"2025","journal-title":"Waste Manag"},{"key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"139842","DOI":"10.1016\/j.scitotenv.2020.139842","article-title":"Manure pretreatments with black soldier fly Hermetia illucens L. 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