{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:22:26Z","timestamp":1787721746467,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Diabetes mellitus affects hundreds of millions of people worldwide and remains a leading cause of multi\u2010organ morbidity. Eriodictyol (Eri), a natural flavonoid enriched in edible plants and other citrus fruits, exhibits antioxidant, anti\u2010inflammatory, and glucose\u2010lowering properties\n                      <jats:italic>in vitro<\/jats:italic>\n                      . However, its systemic efficacy against diabetic hyperglycemia and tissue injury\n                      <jats:italic>in vivo<\/jats:italic>\n                      has not been systematically examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Dietary supplementation with Eri (100 mg kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      day\n                      <jats:sup>\u22121<\/jats:sup>\n                      for 6\u2009weeks) attenuated body\u2010weight loss, polydipsia, and organ hypertrophy in low\u2010dose streptozotocin\u2010induced diabetic mice. Treatment improved glucose tolerance and insulin sensitivity, lowered fasting glucose and homeostatic model assessment of insulin resistance (HOMA\u2010IR), and ameliorated islet injury while restoring the insulin\/glucagon balance. Eri upregulated glucose transporters (\n                      <jats:italic>Glut2<\/jats:italic>\n                      ,\n                      <jats:italic>Glut4<\/jats:italic>\n                      ) and suppressed insulin\u2010signaling inhibitors (\n                      <jats:italic>Ptpn1<\/jats:italic>\n                      ,\n                      <jats:italic>Pten<\/jats:italic>\n                      ,\n                      <jats:italic>Socs3<\/jats:italic>\n                      ). In the liver, it shifted metabolism from gluconeogenesis (\n                      <jats:italic>G6pc<\/jats:italic>\n                      ,\n                      <jats:italic>Pck1<\/jats:italic>\n                      ) toward glycolysis (\n                      <jats:italic>Gck<\/jats:italic>\n                      ,\n                      <jats:italic>Pklr<\/jats:italic>\n                      ) and glycogen synthesis. In skeletal muscle, Eri rescued locomotor impairment, reduced histopathology, increased glycogen content, and restored mitochondrial biogenesis genes (\n                      <jats:italic>Sirt1<\/jats:italic>\n                      ,\n                      <jats:italic>Tfam<\/jats:italic>\n                      ,\n                      <jats:italic>Ppargc1a<\/jats:italic>\n                      ). Systemically, Eri lowered pro\u2010inflammatory cytokines, including tumor necrosis factor\u2010alpha (TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ) and interleukin\u20101 beta (IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ), hepatorenal markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (CRE), and blood urea nitrogen (BUN), and lactic acid. Furthermore, Eri suppressed inflammatory genes (\n                      <jats:italic>Tnf<\/jats:italic>\n                      ,\n                      <jats:italic>Il1b<\/jats:italic>\n                      ,\n                      <jats:italic>Nos2<\/jats:italic>\n                      ), activated antioxidant genes (\n                      <jats:italic>Nfe2l2<\/jats:italic>\n                      ,\n                      <jats:italic>Hmox1<\/jats:italic>\n                      ,\n                      <jats:italic>Nqo1<\/jats:italic>\n                      ), and restored glutathione (GSH) content and antioxidant enzymes, including catalase (CAT) and superoxide dismutase (SOD), while reducing lipid peroxidation (MDA) in both the liver and muscle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Dietary Eri supplementation ameliorates hyperglycemia and multi\u2010organ injury in diabetic mice through coordinated regulation of insulin signaling, glucose metabolism, mitochondrial biogenesis, and inflammatory\/antioxidant responses. These results support its development as a natural, food\u2010derived hypoglycemic nutraceutical for diabetes management. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71005","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:00:46Z","timestamp":1787720446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary eriodictyol ameliorates hyperglycemia and multi\u2010organ damage in streptozotocin\u2010induced diabetic mice: involvement of insulin signaling and antioxidant responses"],"prefix":"10.1002","author":[{"given":"Xu","family":"Deng","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-991X","authenticated-orcid":false,"given":"Chunxia","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Northwest A&amp;F University  Yangling China"},{"name":"College of Chemistry and Chemical Engineering Jinggangshan University  Ji'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S2213-8587(25)00299-2","article-title":"11th edition of the IDF diabetes atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050","volume":"14","author":"Genitsaridi I","year":"2026","journal-title":"Lancet Diabetes Endocrinol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath MY","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/dom.16154","article-title":"Metabolic interventions as adjunctive therapies to insulin in type 1 diabetes: current clinical landscape and perspectives","volume":"27","author":"Podobnik J","year":"2025","journal-title":"Diabetes Obes Metab"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1177\/23743735241257811","article-title":"Can unmet needs be addressed by adjunctive therapies? 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