{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:19:33Z","timestamp":1787721573872,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Climate change\u2010induced heatstroke (HS) presents a critical global public health threat, necessitating the development of preventive strategies using natural, food\u2010derived resources.\n                      <jats:italic>Pogostemon cablin<\/jats:italic>\n                      (patchouli) is a medicinal and edible dual\u2010purpose resource that yields an essential oil (PEO), which serves as a core ingredient in traditional medicines and a promising functional food additive. However, the bioactive basis and mechanisms of PEO in maintaining physiological homeostasis against HS remain to be fully elucidated. This study assessed the protective effects of PEO on intestinal barrier function and immune homeostasis under HS conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Gas chromatography\u2013mass spectrometry analysis identified 42 volatile constituents in PEO, predominantly sesquiterpenes and sesquiterpene alcohols. In an HS mouse model, oral administration of PEO accelerated thermoregulatory recovery and markedly attenuated hepatic and ileal structural damage. Specifically, PEO preserved intestinal barrier integrity by upregulating key tight junction proteins, including Zonula Occludens\u20101 and Occludin. Furthermore, PEO suppressed the systemic pro\u2010inflammatory cytokine storm and modulated immune balance in heat\u2010stressed RAW264.7 macrophages by inhibiting M1 polarization (iNOS, TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ) and promoting M2 markers (Arg1, IL\u201010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These results revealed that PEO serves as a potent effective component that protects against HS\u2010induced injury by reinforcing intestinal barrier function and regulating immune homeostasis. These findings provide theoretical support for the development of PEO as a promising functional food or beverage additive for mitigating heat\u2010related challenges. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71011","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:24:01Z","timestamp":1787718241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>Pogostemon cablin<\/i>\n                    <\/scp>\n                    essential oil: a food\u2010grade natural product attenuating heatstroke\u2010induced multi\u2010organ injury via intestinal barrier reinforcement and macrophage polarization modulation"],"prefix":"10.1002","author":[{"given":"Ruoxi","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co. Ltd &amp; Nanjing University of Chinese Medicine)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Intensive Care Unit General Hospital of Southern Theater Command  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine Intensive Care Unit General Hospital of Southern Theater Command  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (Jiangsu Kanion Pharmaceutical Co. 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