{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:13:38Z","timestamp":1788574418732,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["125Z143"],"award-info":[{"award-number":["125Z143"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC) is a relapsing inflammatory bowel disease characterised by oxidative stress, inflammation and regulated cell death of the colonic mucosa. Because live probiotics may cause bacteraemia and sepsis in immunocompromised hosts, non\u2010viable (paraprobiotic) alternatives have attracted interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This study evaluated the antioxidant, anti\u2010inflammatory and PANoptosis\u2010regulating effects of a heat\u2010inactivated paraprobiotic derived from\n                      <jats:italic>Lactobacillus acidophilus<\/jats:italic>\n                      LA\u20105 in acetic acid (AA)\u2010induced experimental UC, compared to the live probiotic. Forty female Balb\/c mice were assigned to four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910): healthy control, AA colitis, live LA\u20105 (AA\u2010PRO) and heat\u2010inactivated paraprobiotic (AA\u2010PARA). Colitis was induced by intrarectal administration of 4% acetic acid, and treatments were given by oral gavage for 7\u2009days. Disease activity, colon histopathology, oxidant\/antioxidant biomarkers, serum cytokines, PANoptosis\u2010related proteins (western blot) and caecal short\u2010chain fatty acids were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      AA increased the disease activity index, shortened the colon and induced splenomegaly, histopathological damage, oxidative stress and a systemic cytokine surge. Both treatments limited these changes; the paraprobiotic preserved colon length, reversed splenomegaly and regulated interleukin (IL)\u20106\/IL\u201010 more effectively than the live probiotic (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). All elevated PANoptosis markers (NLRP3, c\u2010GSDMD, c\u2010IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , p\u2010RIPK3, p\u2010MLKL, c\u2010caspase\u20103, c\u2010GSDME and ZBP1) were suppressed by both treatments. ZBP1 was suppressed significantly more by the paraprobiotic (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), which also increased butyric and valeric acid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>L. acidophilus<\/jats:italic>\n                      LA\u20105 paraprobiotic exerts protective effects at least equivalent to the live probiotic, supporting its potential as a safe therapeutic candidate for UC. \u00a9 2026 The Author(s).\n                      <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71037","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:46:07Z","timestamp":1788572767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of paraprobiotic\n                    <i>Lactobacillus acidophilus<\/i>\n                    <scp>LA<\/scp>\n                    \u20105 on\n                    <scp>PANoptosis<\/scp>\n                    , oxidative stress and inflammation in acetic acid\u2010induced ulcerative colitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-4306","authenticated-orcid":false,"given":"Adem","family":"Yava\u015f","sequence":"first","affiliation":[{"name":"Food Quality Control and Analysis, Food Processing Department, \u00c7ine Vocational School Ayd\u0131n Adnan Menderes University  Ayd\u0131n 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