{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:18:21Z","timestamp":1788499101680,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018998","name":"Ege University Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018998","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Propolis is a resinous natural product with increasing industrial importance due to its diverse biological activities. However, its standardization remains challenging because its chemical composition varies significantly depending on geographical and botanical origin. Although routine screenings are common, direct isolation studies aiming to identify novel bioactive compounds from propolis remain limited, particularly for Turkish propolis. Therefore, this study aimed to isolate and characterize compounds from propolis samples collected from Rize and Gumushane regions of T\u00fcrkiye.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Phytochemical investigation led to the identification of one new compound, (20\n S<\/jats:italic>\n )\u201012\n \u03b2<\/jats:italic>\n \u2010acetoxy\u201020\u2010hydroxydammaran\u20103\u2010one\u201024\u2010methylene (\n 1<\/jats:bold>\n ), together with six known compounds: isalpinin, galangin, caffeic acid phenethyl ester, phenethyl ferulate, pinocembrin, and tectochrysin. Structures were elucidated using one\u2010dimensional\/two\u2010dimensional (1D\/2D) nuclear magnetic resonance (NMR), and high\u2010resolution mass spectrometry (HRMS) analyses. Cytotoxic activities of the extract and isolated compounds were evaluated against OE33, SK\u2010BR\u20103, ACC\u2010201, and CCD\u201034Lu cell lines by MTT assay. Compound\n 1<\/jats:bold>\n exhibited selective cytotoxic activity against ACC\u2010201 and SK\u2010BR\u20103 cancer cells compared with healthy fibroblast cells.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n These findings demonstrate that Turkish propolis is a valuable source of structurally diverse bioactive compounds. The newly identified dammarane\u2010type compound showed promising selective cytotoxic activity, highlighting its potential for further pharmacological investigations. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.71041","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:47:08Z","timestamp":1788497228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A new dammarane\u2010type triterpene from\n Turkish<\/scp>\n propolis: isolation, characterization, and biological potential"],"prefix":"10.1002","author":[{"given":"Gaye","family":"Sumer Okkali","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ege University Izmir T\u00fcrkiye"},{"name":"Department of Chemistry, Faculty of Science Izmir Institute of Technology Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulce","family":"Gucur","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyku","family":"Erendag","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berkin","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Graduate School of Natural and Applied Sciences, Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Nalbantsoy","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-8561","authenticated-orcid":false,"given":"Nazli","family":"Boke Sarikahya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ege University Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/0005772X.1979.11097738","article-title":"Propolis: a review","volume":"60","author":"Ghisalberti EL","year":"1979","journal-title":"Bee World"},{"key":"e_1_2_10_3_1","first-page":"179","article-title":"The origin of propolis in the theories and scientific research","volume":"54","author":"K\u0119dzia B","year":"2008","journal-title":"Herba Pol"},{"key":"e_1_2_10_4_1","article-title":"Propolis: a wonder bees product and its pharmacological 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