{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:08:33Z","timestamp":1789099713181,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Hyperuricemia is a prevalent metabolic disorder associated with excessive uric acid (UA) accumulation, oxidative stress, renal dysfunction and gut microbiota dysbiosis. Chitooligosaccharide (COS) possesses antioxidant and microbiota\u2010regulating properties; however, the potential of mineral ion\u2010enriched COS formulations against hyperuricemia remains unclear. In this study, a chitooligosaccharide\u2010ionic water (COS\u2010IW) was prepared by incorporating K, Si, B and Mo mineral components into a chitooligosaccharide matrix, followed by low\u2010temperature concentration to obtain a stable functional formulation. The elemental composition and structural characteristics of COS\u2010IW were characterized by inductively coupled plasma optical emission spectrometry, Fourier transform infrared spectroscopy,\n                      <jats:sup>1<\/jats:sup>\n                      H\u2010NMR and X\u2010ray diffraction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In hyperuricemic mice, COS\u2010IW significantly decreased serum UA levels and improved renal function by reducing blood urea nitrogen and creatinine levels, accompanied by suppression of xanthine oxidase and adenosine deaminase activities. COS\u2010IW also exhibited strong DPPH (i.e. 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl) and ABTS [i.e. 2,2'\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid)] radical scavenging activities\n                      <jats:italic>in vitro<\/jats:italic>\n                      and restored renal superoxide dismutase activity at the same time as reducing malondialdehyde accumulation\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Furthermore, COS\u2010IW reshaped gut microbiota composition, restored microbial diversity, and regulated pathways associated with tryptophan metabolism, butanoate metabolism, purine metabolism and urate homeostasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>COS\u2010IW alleviates hyperuricemia through multiple mechanisms involving inhibition of UA production, improvement of renal function, attenuation of oxidative stress and modulation of the gut microbiota\u2013metabolite axis. These findings provide new insights into the application of COS\u2010based mineral ion formulations as functional ingredients for hyperuricemia management. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71069","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:57:43Z","timestamp":1789099063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypouricemic effect and mechanism of chitooligosaccharide\u2010ionic water in hyperuricemic mice"],"prefix":"10.1002","author":[{"given":"Wenqian","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhe","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Sang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenquan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7129-2704","authenticated-orcid":false,"given":"Xiangfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11892-023-01506-2","article-title":"Prevalence of diabetes in patients with hyperuricemia and gout: a systematic review and meta\u2010analysis","volume":"23","author":"Jiang JG","year":"2023","journal-title":"Curr Diab Rep"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.2174\/0929867331666230809143758","article-title":"An updated review for hyperuricemia and gout management; special focus on the available drug delivery systems and clinical trials","volume":"31","author":"Karantas ID","year":"2024","journal-title":"Curr Med Chem"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-024-01916-y","article-title":"Hyperuricemia and its related diseases: mechanisms and advances in therapy","volume":"9","author":"Du L","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1177\/11795468241239542","article-title":"Impact of hyperuricemia and urate\u2010lowering agents on cardiovascular diseases","volume":"18","author":"Sosa F","year":"2024","journal-title":"Clin Med Insights Cardiol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2018.00160","article-title":"Physiology of hyperuricemia and urate\u2010lowering treatments","volume":"5","author":"Benn CL","year":"2018","journal-title":"Front Med"},{"key":"e_1_2_10_7_1","article-title":"Supplements extracted from Lophatherum gracile Brongn. 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