{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:06:43Z","timestamp":1788847603376,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304147"],"award-info":[{"award-number":["82304147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is a prevalent global health concern with limited therapeutic options. Alpha\u2010lipoic acid (ALA), a naturally occurring organosulfur compound with potent antioxidant activity, shows hepatoprotective potential, but its mechanisms along the gut\u2013liver axis remain poorly understood. This study investigated whether ALA ameliorates high\u2010fat diet (HFD)\u2010induced MASLD by repairing the intestinal barrier and restoring gut microbiota\u2010mediated primary bile acid (BA) signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In C57BL\/6 mice fed an HFD with or without ALA supplementation (60\u2009mg\/kg\/d) for 12\u2009weeks, ALA significantly attenuated HFD\u2010induced obesity, dyslipidemia, insulin resistance, and hepatic injury (steatosis, apoptosis, oxidative stress), without altering caloric intake. ALA restored intestinal barrier function by up\u2010regulating tight junction proteins (Occludin, ZO\u20101) and mucin (Muc2), reducing systemic inflammation and metabolic endotoxemia. Integrated 16S rRNA sequencing and targeted BA metabolomics revealed that ALA selectively enriched beneficial gut bacteria (e.g.,\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      ,\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      ) and reversed HFD\u2010induced depletion of primary BAs including cholic acid (CA) and chenodeoxycholic acid (CDCA). These restored primary BAs were positively correlated with the enriched microbial taxa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These findings elucidate a novel \u2018gut microbiota\u2013primary bile acid\u2019 axis underlying the hepatoprotective effects of dietary ALA, supporting its potential as a functional food component or dietary supplement for MASLD management. \u00a9 2026 Society of Chemical Industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71071","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:08:52Z","timestamp":1788844132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary alpha\u2010lipoic acid supplementation alleviates high\u2010fat diet\u2010induced hepatic steatosis and inflammation by remodeling the gut microbiota and restoring the primary bile acid pool"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9517-0813","authenticated-orcid":false,"given":"Pengfei","family":"Ren","sequence":"first","affiliation":[{"name":"Translational Medicine Research Center Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qi","sequence":"additional","affiliation":[{"name":"The First Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biqian","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing and Safety Control College of Food Science and Engineering, Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing and Safety Control College of Food Science and Engineering, Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-5946","authenticated-orcid":false,"given":"Shangyun","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Public Health Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.clinthera.2021.01.007","article-title":"Nonalcoholic fatty liver disease: a global perspective","volume":"43","author":"Wong W\u2010K","year":"2021","journal-title":"Clin Ther"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41574-024-01054-z","article-title":"Modelling human liver disease: from steatotic liver disease to 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