{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:55:47Z","timestamp":1790571347326,"version":"4.1.0"},"reference-count":136,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2100605"],"award-info":[{"award-number":["2023YFD2100605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Carbohydrate\u2010binding modules (CBMs) are independent domains generally appended in carbohydrate\u2010active enzymes (CAZymes) with carbohydrate\u2010binding functions. The primary roles of CBMs in CAZymes include targeting, proximity, disruption, and adhesion effects. Due to their capacity to recognize and bind to specific carbohydrate structures, CBMs have emerged as valuable tools with wide applications, greatly facilitating the research and development of carbohydrates. This review summarizes the recent research progress and applications of CBMs, with particular emphasis on their applications as: (i) molecular probes, (ii) fusion partners, and (iii) connection bridges, especially in the last decade. Future efforts in the field of CBMs should focus on the development of specificity prediction tools, and investigations of their interactions with oligosaccharides and their biochemical properties. Furthermore, novel applications of CBMs, including the purification of structurally defined carbohydrates, are expected to be further explored. \u00a9 2026 Society of Chemical Industry.<\/jats:p>","DOI":"10.1002\/jsfa.71113","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:17:01Z","timestamp":1790569021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carbohydrate\u2010binding modules: powerful tools in the research and development of carbohydrates \u2013 a review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1769-5197","authenticated-orcid":false,"given":"Xuanwei","family":"Mei","sequence":"first","affiliation":[{"name":"Institute of Medicine and Food Homology &amp; Traditional Chinese Medicine Health, College of Agricultural Engineering and Food Science Shandong University of Technology  Zibo China"},{"name":"Shandong Key Laboratory of Biological Preparation and Application Technology for Functional Glycomics, Baolingbao Biology Co. Ltd, Yucheng  Dezhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Medicine and Food Homology &amp; Traditional Chinese Medicine Health, College of Agricultural Engineering and Food Science Shandong University of Technology  Zibo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewen","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Key Laboratory of Biological Preparation and Application Technology for Functional Glycomics, Baolingbao Biology Co. Ltd, Yucheng  Dezhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Medicine and Food Homology &amp; Traditional Chinese Medicine Health, College of Agricultural Engineering and Food Science Shandong University of Technology  Zibo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-7272","authenticated-orcid":false,"given":"Yaoguang","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing &amp; Safety Control College of Food Science and Engineering, Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1042\/BJ20040892","article-title":"Carbohydrate\u2010binding modules: fine\u2010tuning polysaccharide recognition","volume":"382","author":"Boraston AB","year":"2004","journal-title":"Biochem J"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00871","article-title":"Carbohydrate binding modules: diversity of domain architecture in amylases and cellulases from filamentous microorganisms","volume":"8","author":"Sidar A","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jmb.2007.01.030","article-title":"Identification and characterization of a novel periplasmic polygalacturonic acid binding protein from Yersinia enterolitica","volume":"367","author":"Abbott DW","year":"2007","journal-title":"J Mol Biol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.sbi.2014.07.004","article-title":"Using structure to inform carbohydrate binding module function","volume":"28","author":"Abbott DW","year":"2014","journal-title":"Curr Opin Struct Biol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1016\/S0021-9258(19)81530-2","article-title":"Precise excision of the cellulose binding domains from two Cellulomonas fimi cellulases by a homologous protease and the effect on catalysis","volume":"263","author":"Gilkes NR","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1432-1033.1988.tb13736.x","article-title":"Studies of the cellulolytic system of Trichoderma reesei QM 9414. 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