{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:40:28Z","timestamp":1792647628162,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Diets rich in plant\u2010based proteins are becoming increasingly popular, but the safety of extracted oat (\n                      <jats:italic>Avena sativa<\/jats:italic>\n                      L.) protein in relation to cardiometabolic and endocrine risks remains unexplored. This study evaluated the safety of oat protein by analyzing anthropometric, hematological, biochemical, and histopathological parameters in male Wistar rats fed high\u2010protein diets for 30 or 90\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Animals were divided into four diet groups (\n                      <jats:italic>n<\/jats:italic>\n                      =\u20096 per group): oat protein\u2010supplemented (G1), soy protein\u2010supplemented (G2), casein\u2010supplemented (G3), and control (G4). After 30\u2009days, the oat protein group had significantly higher leukocyte (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.018) and lymphocyte (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.001) counts than the other groups. After 90\u2009days, this group had significantly lower erythrocyte counts (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.007), hemoglobin levels (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.017), hematocrit values (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.011), total leukocyte counts (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.001), lymphocyte counts (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.001), and platelet counts (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.001) than the other groups. Oat protein supplementation improved lipid parameters, reducing low\u2010density lipoprotein (LDL) cholesterol (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.034) after 30\u2009days and triglycerides (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.003) and very\u2010low\u2010density lipoprotein (VLDL) cholesterol (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.003) after 90\u2009days, with effects similar to those observed in the casein group. Increased creatinine levels (\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.005) were observed in the oat protein group after 30\u2009days, suggesting a transient renal effect. Histopathological analysis revealed mild to moderate alterations in liver and kidney tissues, including neutrophil infiltration in all groups and the presence of macrophages and mononuclear cells in the renal interstitium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Although oat protein supplementation improved lipid profile parameters, prolonged high intake was associated with hematological alterations and transient renal changes. These results highlight the need for caution in the use of high\u2010protein diets based on plant sources and underscore the importance of further studies to clarify their long\u2010term safety. \u00a9 2026 The Author(s).\n                      <jats:italic>Journal of the Science of Food and Agriculture<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71164","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:34:21Z","timestamp":1792647261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of oat protein on hematological parameters and metabolism in Wistar rats"],"prefix":"10.1002","author":[{"given":"Gabriela Matte","family":"Bertoldi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Regional 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Mori","family":"Viero","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Regional University of the Northwest of the State of Rio Grande do Sul  Iju\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Andr\u00e9ia","family":"Inkelmann","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Regional University of the Northwest of the State of Rio Grande do Sul  Iju\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio Gonzalez","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Agronomy Northwest Regional University of the State of Rio Grande do Sul  Iju\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Ricardo","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Agronomy Northwest 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