{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:44:13Z","timestamp":1791971053568,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Fermentation may enhance the bioactivity of\n                      <jats:italic>Sargassum<\/jats:italic>\n                      soluble dietary fiber (SDF). This study investigates the preventive effects of\n                      <jats:italic>Bifidobacterium longum<\/jats:italic>\n                      fermented\n                      <jats:italic>Sargassum<\/jats:italic>\n                      SDF (BL\u2010SDF) against oxidative stress and inflammatory bowel disease (IBD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      , the BL\u2010SDF significantly reduced nitric oxide (NO) production by 16.98\u201323.04% and reactive oxygen species (ROS) accumulation by 65.30\u201381.28% in lipopolysaccharide (LPS)\u2010stimulated RAW264.7 macrophages, increased superoxide dismutase (SOD) and catalase (CAT) activities, decreased malondialdehyde (MDA), and suppressed prostaglandin E2 (PGE2), interleukin\u20106 (IL\u20106), tumor necrosis factor alpha (TNF\u2010\u03b1), and interleukin\u20101 beta (IL\u20101\u03b2). In dextran sulfate sodium (DSS)\u2010induced C57BL\/6 mice, pre\u2010administration of BL\u2010SDF alleviated weight loss and colonic damage, enhanced antioxidant enzymes activities (SOD, CAT, and glutathione peroxidase (GSH\u2010Px)), and reduced MDA and NO levels in the colon. Additionally, 16S ribosomal RNA (rRNA) sequencing analysis further indicated enrichment of\n                      <jats:italic>Incertae_Sedis<\/jats:italic>\n                      group,\n                      <jats:italic>Faecalibaculum<\/jats:italic>\n                      , and\n                      <jats:italic>Roseburia<\/jats:italic>\n                      , and gas chromatography\u2013mass spectrometry (GC\u2013MS) revealed elevation of acetic acid, propionic acid, butyric acid, and valeric acid (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Concurrently, BL\u2010SDF significantly reduced the expression of pro\u2010inflammatory cytokines including TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, and interleukin\u201023 (IL\u201023).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      BL\u2010SDF alleviates intestinal inflammation by enhancing antioxidant activities and modulating gut microbiota, suggesting that fermented\n                      <jats:italic>Sargassum<\/jats:italic>\n                      SDF may serve as a dietary strategy for preventing inflammatory bowel disease. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71167","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:44:37Z","timestamp":1791967477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>Sargassum<\/i>\n                    <\/scp>\n                    soluble dietary fiber alleviates oxidative stress and gut microbiota dysbiosis to prevent inflammatory bowel disease in C57BL\/6 mice"],"prefix":"10.1002","author":[{"given":"Hongying","family":"Cai","sequence":"first","affiliation":[{"name":"Shenzhen Research Institute, Guangdong Ocean University  Shenzhen China"},{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Product of 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