{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:40:26Z","timestamp":1792428026605,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Lilium lancifolium<\/jats:italic>\n                      Thunb. (tiger lily) is widely utilized in East Asia for its medicinal and edible bulb, whereas its aerial parts (leaves and stems) are largely discarded despite containing potentially valuable polyphenolic constituents. This study investigated how different drying methods affect the polyphenolic composition and anti\u2010inflammatory activity, and explored associated transcriptional responses related to inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Eight target polyphenols were detected and quantified across leaf and stem samples using high\u2010performance liquid chromatography, with regaloside A and regaloside C as the dominant constituents. Drying methods markedly influenced polyphenol stability: vacuum drying increased the summed concentration of quantified polyphenols in leaves and partially preserved these constituents in stems, whereas hot\u2010air and natural\u2010air drying caused substantial degradation. In a lipopolysaccharide\u2010induced zebrafish inflammation model, stem extracts from fresh and vacuum\u2010dried samples exhibited the strongest inhibition of NO and pro\u2010inflammatory cytokines (TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , IL\u20106, IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ). For leaves, the response varied by inflammatory endpoint: fresh leaf extract showed the greatest reductions in NO and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , whereas IL\u20106 and IL\u201010 did not differ significantly among the extract\u2010treated groups. RT\u2010qPCR analysis demonstrated that fresh stem and leaf extracts downregulated pro\u2010inflammatory gene expression while upregulating\n                      <jats:italic>il10<\/jats:italic>\n                      , with higher concentrations showing transcriptional changes consistent with attenuation of NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B\/MAPK\u2010associated inflammatory responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Drying methods profoundly influence the chemical composition and bioactivity of\n                      <jats:italic>L. lancifolium<\/jats:italic>\n                      aerial parts. Vacuum drying showed tissue\u2010dependent advantages in polyphenol preservation, while inflammation\u2010related activity varied according to tissue and endpoint. These findings highlight the potential of leaves and stems as sustainable resources for developing natural anti\u2010inflammatory agents and promote their high\u2010value utilization. \u00a9 2026 Society of Chemical Industry.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.71173","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:54:54Z","timestamp":1792425294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of drying methods on polyphenolic composition and anti\u2010inflammatory activity of\n                    <i>Lilium lancifolium<\/i>\n                    leaves and stems"],"prefix":"10.1002","author":[{"given":"Peiyao","family":"Yu","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zang's Medicine Resources Conservation and Utilization of Xizang Autonomous Region, The Provincial and Ministerial Co\u2010founded Collaborative Innovation Center for R and D in Xizang Characteristic Agricultural and Animal Husbandry Resources, Xizang Traditional Chinese (Zang's) Medicine Resource Center, Joint Laboratory for Zang's Materia Medica Resources Scientific Protection and Utilization Research of Zang's Medical Research Center of Xizang Xizang Agricultural and Animal..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Quan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zang's Medicine Resources Conservation and Utilization of Xizang Autonomous Region, The Provincial and Ministerial Co\u2010founded Collaborative Innovation Center for R and D in Xizang Characteristic Agricultural and Animal Husbandry Resources, Xizang Traditional Chinese (Zang's) Medicine Resource Center, Joint Laboratory for Zang's Materia Medica Resources Scientific Protection and Utilization Research of Zang's Medical Research Center of Xizang Xizang Agricultural and Animal..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zang's Medicine Resources Conservation and Utilization of Xizang Autonomous Region, The Provincial and Ministerial Co\u2010founded Collaborative Innovation Center for R and D in Xizang Characteristic Agricultural and Animal Husbandry Resources, Xizang Traditional Chinese (Zang's) Medicine Resource Center, Joint Laboratory for Zang's Materia Medica Resources Scientific Protection and Utilization Research of Zang's Medical Research Center of Xizang Xizang Agricultural and Animal..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Lan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zang's Medicine Resources Conservation and Utilization of Xizang Autonomous Region, The Provincial and Ministerial Co\u2010founded Collaborative Innovation Center for R and D in Xizang Characteristic Agricultural and Animal Husbandry Resources, Xizang Traditional Chinese (Zang's) Medicine Resource Center, Joint Laboratory for Zang's Materia Medica Resources Scientific Protection and Utilization Research of Zang's Medical Research Center of Xizang Xizang Agricultural and 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