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Previously, we have reported that <jats:italic>E. kansui<\/jats:italic> increases interferon\u2010gamma (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3) production in natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells. However, it is not clear how <jats:italic>E. kansui<\/jats:italic> regulates <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 secretion by <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In this study, <jats:italic>E. kansui<\/jats:italic> was separated into six individual compounds from the same chloroform fraction so that the activity of each compound could be compared. <jats:italic>E. kansui<\/jats:italic> compounds induced <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 secretion through the phosphorylation of protein kinase D and <jats:styled-content style=\"fixed-case\">I\u03baB<\/jats:styled-content> kinase pathways. Furthermore, <jats:italic>E. kansui<\/jats:italic> compounds activated the translocation of p65, a sub\u2010unit of nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells (<jats:styled-content style=\"fixed-case\">NF\u2010\u03baB<\/jats:styled-content>), to the nucleus and induced <jats:styled-content style=\"fixed-case\">NF\u2010\u03baB<\/jats:styled-content> at the transcriptional level.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>These findings suggest that <jats:italic>E. kansui<\/jats:italic> enhances <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 secretion through the <jats:styled-content style=\"fixed-case\">NF\u2010\u03baB<\/jats:styled-content> pathway in <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells. \u00a9 2015 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.7380","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T05:25:28Z","timestamp":1439875528000},"page":"2635-2640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ingenane\u2010type diterpene compounds from <i>Euphorbia kansui<\/i> modulate <scp>IFN<\/scp>\u2010\u03b3 production through <scp>NF\u2010\u03baB<\/scp> activation"],"prefix":"10.1002","volume":"96","author":[{"given":"Sehyun","family":"Oh","sequence":"first","affiliation":[{"name":"Biomedical Genomics Research Center Korea Research Institute of Bioscience and Biotechnology  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Woo","family":"Oh","sequence":"additional","affiliation":[{"name":"Industrial Bio\u2010materials Research Center Korea Research Institute of Bioscience and Biotechnology  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha\u2010Reum","family":"Lee","sequence":"additional","affiliation":[{"name":"Biomedical Genomics Research Center Korea Research Institute of Bioscience and Biotechnology  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"ENZYCHEM Lifesciences  103\u20106, KAIST\u2010ICC F741 Munjidong Daejeon 305\u2010732 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei\u2010Ryang","family":"Oh","sequence":"additional","affiliation":[{"name":"Natural Medicine Researach Center Korea Research Institute of Bioscience and Biotechnology  30 Yeongudanji\u2010ro, Ochang\u2010eup Cheongwon\u2010gun Chungbuk Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Eun","family":"Ko","sequence":"additional","affiliation":[{"name":"Biomedical Genomics 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