{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:41:43Z","timestamp":1790934103618,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"crossref","award":["PEst-OE\/AGR\/UI0690\/2014"],"award-info":[{"award-number":["PEst-OE\/AGR\/UI0690\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Programa Compromisso com Ci\u00eancia 2008"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The liver is one of the most important organs of human body, being involved in several vital functions and regulation of physiological processes. Given its pivotal role in the excretion of waste metabolites and drugs detoxification, the liver is often subjected to oxidative stress that leads to lipid peroxidation and severe cellular damage. The conventional treatments of liver diseases such as cirrhosis, fatty liver and chronic hepatitis are frequently inadequate due to side effects caused by hepatotoxic chemical drugs. To overcome this problematic paradox, medicinal plants, owing to their natural richness in phenolic compounds, have been intensively exploited concerning their extracts and fraction composition in order to find bioactive compounds that could be isolated and applied in the treatment of liver ailments. The present review aimed to collect the main results of recent studies carried out in this field and systematize the information for a better understanding of the hepatoprotective capacity of medicinal plants in <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> systems. Generally, the assessed plant extracts revealed good hepatoprotective properties, justifying the fractionation and further isolation of phenolic compounds from different parts of the plant. Twenty\u2010five phenolic compounds, including flavonoids, lignan compounds, phenolic acids and other phenolic compounds, have been isolated and identified, and proved to be effective in the prevention and\/or treatment of chemically induced liver damage. In this perspective, the use of medicinal plant extracts, fractions and phenolic compounds seems to be a promising strategy to avoid side effects caused by hepatotoxic chemicals. \u00a9 2015 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/jsfa.7446","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T06:54:56Z","timestamp":1441263296000},"page":"1068-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects"],"prefix":"10.1002","volume":"96","author":[{"given":"Carla","family":"Pereira","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), ESA Instituto Polit\u00e9cnico de Bragan\u00e7a  Campus de Santa Apol\u00f3nia 1172 5301\u2010855 Bragan\u00e7a Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), ESA Instituto Polit\u00e9cnico de Bragan\u00e7a  Campus de Santa Apol\u00f3nia 1172 5301\u2010855 Bragan\u00e7a Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel CFR","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), ESA Instituto Polit\u00e9cnico de Bragan\u00e7a  Campus de Santa Apol\u00f3nia 1172 5301\u2010855 Bragan\u00e7a Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"302","article-title":"Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride\u2010induced hepatotoxicity in rats","volume":"37","author":"Ahsan MR","year":"2009","journal-title":"Eur J Sci Res"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.127.1503"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.03.039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787909587"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.10.028"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1093\/ajcn\/57.5.715S","article-title":"Lipid peroxidation: its mechanism, measurement, and significance","volume":"57","author":"Halliwell B","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90478-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01182-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/np970237h"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.47.357"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02227-9"},{"key":"e_1_2_8_14_1","first-page":"255","article-title":"Preliminary evaluation of the anti\u2010hepatotoxic activity of Phyllanthus kozhikodianus, Phyllanthus maderspatensis and Solanum indicum","volume":"59","author":"Asha VV","year":"1998","journal-title":"Fitoterapia"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(79)90223-5"},{"key":"e_1_2_8_16_1","first-page":"2439","article-title":"Alchornea cordifolia extract protects Wistar albino rats against acetaminophen induced liver damage","volume":"5","author":"Olaleye MT","year":"2006","journal-title":"Afr J Biotechnol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/890842"},{"key":"e_1_2_8_18_1","first-page":"47","volume-title":"The Wealth of India: A dictionary of Indian raw materials and industrial products national institutes of science communication, council of scientific and industrial research","author":"Anonymous","year":"2000"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00225-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.08.008"},{"key":"e_1_2_8_21_1","first-page":"654","article-title":"Studies on Phyllanthus amarus","volume":"34","author":"Sane RT","year":"1997","journal-title":"Indian Drugs\u00a0\u2013\u00a0Part II"},{"key":"e_1_2_8_22_1","first-page":"56","volume-title":"Chinese Medicinal Herbs","author":"Editorial Committee of Chinese Medicinal Herbs","year":"1999"},{"key":"e_1_2_8_23_1","first-page":"33","article-title":"Anti\u2010inflammatory and immune experiment of Abrus cantoniensis and Abrus mollis","volume":"26","author":"Zhou F","year":"2005","journal-title":"Yunnan J Trad Chin Med Mater Med"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.08.043"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.04.032"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.11.050"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.10.046"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.08.015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.06.014"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2014.06.006"},{"key":"e_1_2_8_31_1","first-page":"2455","article-title":"Silibinin inhibits tumor growth in a murine orthotopic hepatocarcinoma model and activates the TRAIL apoptotic signaling pathway","volume":"32","author":"Bousserouel S","year":"2012","journal-title":"Anticancer Res"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.01.011"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jyp.2013.12.003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2012.10.019"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.10.024"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(87)90063-6"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.06.060"},{"key":"e_1_2_8_38_1","first-page":"489","article-title":"HM and Duh PD","volume":"4","author":"Wang BS","year":"2012","journal-title":"Comparison of the hepatoprotective activity between cultured Cordyceps militaris and natural Cordyceps sinensis. J Funct Foods"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86110-H"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.052"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.01.008"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2010.04.001"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2012.29.6"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.11.022"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2012.05.008"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00117-6"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.11.020"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2429"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00834K"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.06.061"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1998.tb01670.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161-008-9067-7"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHYT.0000045494.98645.a3"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)80428-8"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)85485-0"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02657682"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.04.015"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjsfa.7446","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjsfa.7446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.7446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:43:11Z","timestamp":1760874191000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.7446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,25]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/jsfa.7446"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.7446","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,25]]},"assertion":[{"value":"2015-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}