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Monounsaturated fatty acids are reported to prevent atherosclerosis; emu oil is a rich source of monounsaturated fatty acid, and we hypothesize that emu oil supplementation could lower inflammation and prevent atherosclerosis in diet\u2010induced obese (<jats:styled-content style=\"fixed-case\">DIO<\/jats:styled-content>) animals. Male Wistar rats were randomly divided into five groups (<jats:italic>n<\/jats:italic> = 6), and fed with normal diet (chow pellet; <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>), or with cafeteria diet (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>), or with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> along with emu oil supplementation at three different doses: <jats:styled-content style=\"fixed-case\">ED1<\/jats:styled-content> (2 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">ED2<\/jats:styled-content> (4 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">ED3<\/jats:styled-content> (8 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) kg<jats:sup>\u22121<\/jats:sup> body weight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After 12 weeks, the animals were sacrificed and serum was analysed for measuring lipid profile, C\u2010reactive proteins, testosterone and luteinizing hormone. Histopathological studies were performed to observe atherogenic changes in thoracic aorta. Restoration of altered lipid and hormonal profiles, and inhibition of atherogenic changes in thoracic aorta, were observed with supplementation of emu oil, confirming its anti\u2010atherosclerotic activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The high content of oleic acid in emu oil could have orchestrated \u2013 either solely or in combination with linoleic and linolenic acids \u2013 causing the upregulation of testosterone biosynthesis and inhibition of atheromatous plaque formation in diet\u2010induced obese animals. \u00a9 2015 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.7480","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T03:05:00Z","timestamp":1443495900000},"page":"3063-3068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Emu oil decreases atherogenic plaque formation in cafeteria diet\u2010induced 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