{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:16:57Z","timestamp":1787851017741,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["AGL2005\u201008088\u2010C02\u201001"],"award-info":[{"award-number":["AGL2005\u201008088\u2010C02\u201001"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n \n White tea infusion (\n Camelia sinensis<\/jats:italic>\n ) has antioxidants properties. The infusion contains polyphenols that have been proposed to induce antioxidant response element (\n ARE<\/jats:styled-content>\n ) response via nuclear factor\n E2<\/jats:styled-content>\n \u2010related factor 2 (\n NRF2<\/jats:styled-content>\n ). Adriamycin (\n ADR<\/jats:styled-content>\n ) has antitumour properties and oxidative effects. Oxidative stress is related to a variety of kidney diseases. Prevention of the oxidative stress through long\u2010term intake of white tea and the study of the molecular mechanisms involved in protection could be of great interest. Rats were given distilled water, 0.015 or 0.045\u2009g of solid white tea extract kg\n \u22121<\/jats:sup>\n body weight for 12 months. Animals received an injection of\n ADR<\/jats:styled-content>\n . In kidney, oxidative stress parameters were measured, the expressions of nuclear factor\n E2<\/jats:styled-content>\n \u2010related factor 2 gene (\n Nrf2<\/jats:italic>\n ), and detoxifying and antioxidants genes were analysed, and the activities of catalase (\n CAT<\/jats:styled-content>\n ), superoxide dismutase (\n SOD<\/jats:styled-content>\n ) and glutathione reductase (\n GR<\/jats:styled-content>\n ) were measured.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n ADR<\/jats:styled-content>\n administration increased oxidative parameters and decreased the antioxidant activity; significantly increased the expression of analysed genes and the activity of\n CAT<\/jats:styled-content>\n and\n SOD<\/jats:styled-content>\n and decreased\n GR<\/jats:styled-content>\n activity. The highest white tea dose protected redox status and inhibited\n ARE<\/jats:styled-content>\n response.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Long\u2010term intake of white tea protected kidney against the oxidative stress.\n ADR<\/jats:styled-content>\n activated the\n ARE<\/jats:styled-content>\n response but in animals treated with the highest dose of white tea, this response was inhibited, probably for antioxidant protection. \u00a9 2015 Society of Chemical Industry\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jsfa.7483","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T01:49:08Z","timestamp":1444096148000},"page":"3079-3087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Long\u2010term intake of white tea prevents oxidative damage caused by adriamycin in kidney of rats"],"prefix":"10.1002","volume":"96","author":[{"given":"Crist\u00f3bal","family":"Espinosa","sequence":"first","affiliation":[{"name":"Physiology Department, Faculty of Biology University of Murcia 30100 Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"L\u00f3pez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Physiology Department, Faculty of Biology University of Murcia 30100 Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"P\u00e9rez\u2010Llamas","sequence":"additional","affiliation":[{"name":"Physiology Department, Faculty of Biology University of Murcia 30100 Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco A","family":"Guardiola","sequence":"additional","affiliation":[{"name":"Fish Innate Immune System Group, Department of Cell Biology and Histology Faculty of Biology, University of Murcia 30100 Murcia 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