{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:40Z","timestamp":1786978120440,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["NRC\u20109210"],"award-info":[{"award-number":["NRC\u20109210"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Osteoarthritis (\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      ) is one of the commonest forms of musculoskeletal disorders that leads to joint degeneration and has a major impact on patients' quality of life. Experimental and\n                      <jats:italic>in vitro<\/jats:italic>\n                      studies have suggested the protective roles of pomegranate juice (\n                      <jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content>\n                      ) as a rich antioxidant source for mitigating cartilage inflammation. In this interventional study, 38 patients with knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      were randomly divided into two groups:\n                      <jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content>\n                      or control for 6 weeks to evaluate the effect of this intervention on clinical signs, inflammation and antioxidant status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Significant decreases in Western Ontario and\n                      <jats:styled-content style=\"fixed-case\">McMaster<\/jats:styled-content>\n                      Universities Osteoarthritis index (\n                      <jats:styled-content style=\"fixed-case\">WOMAC<\/jats:styled-content>\n                      ) total score (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01), stiffness score (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.00) and physical function score (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01) were observed in\n                      <jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content>\n                      group after the intervention. The means of serum levels of matrix metalloproteinase (\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      )\u201013 was significantly decreased (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02) and glutathione peroxidase was increased in the intervention group compared with the control group after the study period (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      According to the findings of this clinical trial,\n                      <jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content>\n                      consumption can improve physical function and stiffness, decrease breakdown cartilage enzymes and increase antioxidant status in patients with knee\n                      <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                      . \u00a9 2016 Society of Chemical Industry\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jsfa.7647","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T04:04:49Z","timestamp":1453694689000},"page":"4377-4381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis"],"prefix":"10.1002","volume":"96","author":[{"given":"Nasrin","family":"Ghoochani","sequence":"first","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Centre Ahvaz Jundishapur University of Medical Sciences  Ahvaz 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