{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:24:24Z","timestamp":1788506664641,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T00:00:00Z","timestamp":1464652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["233241"],"award-info":[{"award-number":["233241"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Inulin and other fructans are synthesized and stored in mezcal agave (<jats:italic>Agave salmiana<\/jats:italic>). Fructans provide several health benefits and have excellent technological properties, but only few data report their physiological effect when added in the diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Here, we studied the physiological effects of fructans obtained from <jats:italic>A. salmiana<\/jats:italic> when added in the diet of Wistar rats. Results showed favorable changes on Wistar rats when the fructans was added to their diet, including the decrease of the <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> in the feces and the increase of the number of lactic acid bacteria (<jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content> g<jats:sup>\u22121<\/jats:sup>) (<jats:italic>Lactobacillus<\/jats:italic> spp. and <jats:italic>Bifidobacterium<\/jats:italic> spp.), even these changes were enhanced with the synbiotic diet (fructans plus <jats:italic>B. animalis<\/jats:italic> subsp. <jats:italic>lactis<\/jats:italic>). Synbiotic diet, developed changes in the reduction of cholesterol and triglycerides concentrations in serum, with statistical differences (<jats:italic>P<\/jats:italic> &lt; 0.05). Histological analysis of colon sections showed that synbiotic diet promoted colon cells growth suggesting that fructans from <jats:italic>A. salmiana<\/jats:italic> confer beneficial health effects through gut microbiota modulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our data underline the advantage of targeting the gut microbiota by colonic nutrients like specific structure of fructans from <jats:italic>A. salmiana<\/jats:italic>, with their beneficial effects. More studies are necessary to define the role of fructans to develop more solid therapeutic solutions in humans. \u00a9 2016 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.7764","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T11:33:11Z","timestamp":1461238391000},"page":"556-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of prebiotics of <i>Agave salmiana<\/i> fed to healthy Wistar rats"],"prefix":"10.1002","volume":"97","author":[{"given":"Iliana","family":"Jasso\u2010Padilla","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Quimicas Universidad Autonoma de San Luis Potosi  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha","family":"Ju\u00e1rez\u2010Flores","sequence":"additional","affiliation":[{"name":"Instituto de Investigacion de Zonas Deserticas Universidad Autonoma de San Luis Potosi  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