{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:22:56Z","timestamp":1773112976575,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Nutrition and Food Technology Research Institute of the Shahid Beheshti University"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The effects of pomegranate juice (<jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content>) on the risk factors of non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>)\/non\u2010alcoholic steatohepatitis (<jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>) have been reported previously; however, the effects on <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> and its prevention have not yet been clarified. The present study aimed to evaluate the effects of <jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content> consumption with respect to the prevention of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> development. Sprague\u2013Dawley rats were fed either a high\u2010fat, high sugar diet (model group); a high\u2010fat, high sugar diet plus <jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content> (model+<jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content>); or a chow diet <jats:italic>ad libitum<\/jats:italic> for 7 weeks. Serum levels of fasting glucose, triglyceride, cholesterol, liver enzymes, insulin and hepatic tumor necrosis factor\u2010\u03b1 and tissue growth factor\u2010\u03b2 gene expression were determined. Hepatic histology was examined by hemotoxylin and eosin staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The model+<jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content> group had significantly lower hepatic steatosis, ballooning, lobular inflammation and portal inflammation (<jats:italic>P<\/jats:italic> &lt; 0.001); lower hepatic pro\u2010inflammatory and pro\u2010fibrotic gene expression (<jats:italic>P<\/jats:italic> &lt; 0.001); and lower plasma levels of alanine aminotransferase (<jats:italic>P<\/jats:italic> = 0.026), aspartate aminotransferase (<jats:italic>P<\/jats:italic> = 0.041), insulin (<jats:italic>P<\/jats:italic> &lt; 0.001), triglycerides (<jats:italic>P<\/jats:italic> = 0.041) and glucose (<jats:italic>P<\/jats:italic> = 0.009) compared to the model group; however, weight gain, food intake and plasma high\u2010density lipoprotein levels were not significantly different between these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The data obtained in the present study indicate that the regular consumption of <jats:styled-content style=\"fixed-case\">PJ<\/jats:styled-content> can prevent <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> even in the presence of the other risk factors such as obesity, hypercholesterolemia, and high energy, fat and sugar intakes. \u00a9 2016 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8042","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T09:38:10Z","timestamp":1474537090000},"page":"2327-2332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Pomegranate juice prevents development of non\u2010alcoholic fatty liver disease in rats by attenuating oxidative stress and 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