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The aim was to produce and characterize peptides from common bean protein isolates and evaluate their potential to inhibit markers of type\u20102 diabetes, hypertension and oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Mexican black and Brazilian Carioca bean isolated proteins were characterized after pepsin\/pancreatin digestion. Also, four synthesized pure peptides, originally found in these beans, were evaluated. Bean protein digests and pure peptides exerted dipeptidyl peptidase\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DPP\u2010IV<\/jats:styled-content>) inhibition (<jats:styled-content style=\"fixed-case\">IC<jats:sub>50<\/jats:sub><\/jats:styled-content> = 0.03\u20130.87 mg dry weight (<jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>). Lineweaver\u2013Burk plots and computational modeling showed competitive inhibition of <jats:styled-content style=\"fixed-case\">DPP\u2010IV<\/jats:styled-content>. Angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) inhibition ranged from <jats:styled-content style=\"fixed-case\">IC<jats:sub>50<\/jats:sub><\/jats:styled-content> = 0.09 to 0.99 mg <jats:styled-content style=\"fixed-case\">DW mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>, and <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibition ranged from 36.3 to 50.1% mg<jats:sup>\u22121<\/jats:sup> <jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>. Carioca Perola bean digested proteins presented the highest antioxidant capacity (269.3 mmol L<jats:sup>\u22121<\/jats:sup> Trolox equivalent g<jats:sup>\u22121<\/jats:sup> <jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>) as the peptide <jats:styled-content style=\"fixed-case\">KTYGL<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &gt; 0.05) with the most potent <jats:styled-content style=\"fixed-case\">DPP\u2010IV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibition.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Peptides from common bean have antidiabetic and antihypertensive potential regardless of their antioxidant capacity. \u00a9 2016 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8053","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T11:36:51Z","timestamp":1474717011000},"page":"2401-2410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type\u20102 diabetes, hypertension and oxidative stress"],"prefix":"10.1002","volume":"97","author":[{"given":"Luis","family":"Mojica","sequence":"first","affiliation":[{"name":"Department of Food Science and Human Nutrition University of Illinois at Urbana\u2010Champaign  228 ERML Bldg, 1201 West Gregory Drive Urbana IL 61801 USA"},{"name":"Tecnolog\u00eda Alimentaria Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A. 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