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Diabetes was induced by single intraperitoneal injection of alloxan (150 mg kg<jats:sup>\u22121<\/jats:sup>). However, the extracts at various doses or glibenclamide (<jats:styled-content style=\"fixed-case\">GLB<\/jats:styled-content>, 10 mg kg<jats:sup>\u22121<\/jats:sup> body weight) were given by oral administration for 2 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ICPAE<\/jats:styled-content> (50\u20132000 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) exerted dose\u2010dependent reduction of sodium\u2010dependent glucose transport across isolated mice jejunum and the maximal inhibition exceeded 50%.The <jats:styled-content style=\"fixed-case\">ICPAE<\/jats:styled-content> treatment improved glucose tolerance. More importantly, <jats:styled-content style=\"fixed-case\">ICPAE<\/jats:styled-content> at various doses showed a significant reduction in blood glucose and biochemical profiles in diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our findings confirm that the degree of maturity of carob characterized by a different phytochemical composition may be responsible for these actions. Therefore, these compounds may be used as a food supplement in hyperglycemia and diabetes treatments. \u00a9 2016 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8091","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T04:03:58Z","timestamp":1476417838000},"page":"2664-2670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["<i>Ceratonia siliqua<\/i> L. 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