{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T20:03:28Z","timestamp":1781726608956,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["NSERC"],"award-info":[{"award-number":["NSERC"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>An increased rate of high blood pressure has led to critical human hypertensive conditions in most nations. In the present study, bambara protein hydrolysates (<jats:styled-content style=\"fixed-case\">BPHs<\/jats:styled-content>) obtained using three different proteases (alcalase, trypsin and pepsin) and their peptide fractions (molecular weight: 10, 5, 3 and 1 <jats:styled-content style=\"fixed-case\">kDa<\/jats:styled-content>) were investigated for antihypertensive and antioxidant activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Alcalase hydrolysate contained the highest amount of low molecular weight (<jats:styled-content style=\"fixed-case\">LMW<\/jats:styled-content>) peptides compared to pepsin and trypsin hydrolysates. <jats:styled-content style=\"fixed-case\">LMW<\/jats:styled-content> peptides fractions (&lt;1 <jats:styled-content style=\"fixed-case\">kDa<\/jats:styled-content>) exhibited the highest inhibitory activity against angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) for all the enzymes hydrolysates. For renin inhibition, alcalase hydrolysate showed the highest inhibition at 59% compared to other hydrolysates and their corresponding membrane fractions. The antioxidant power of bambara protein hydrolysates and peptide fractions was evaluated through the inhibition of linoleic acid peroxidation and <jats:styled-content style=\"fixed-case\">ABTS<\/jats:styled-content> scavenging activity. Among the hydrolysates, alcalase exhibited the highest inhibition of linoleic acid oxidation. Furthermore, all <jats:styled-content style=\"fixed-case\">BPHs<\/jats:styled-content> were able to scavenge <jats:styled-content style=\"fixed-case\">ABTS<\/jats:styled-content><jats:sup>\u2022+<\/jats:sup> to a three\u2010fold greater extent compared to the isolate.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LMW<\/jats:styled-content> peptide fractions could potentially serve as useful ingredients in the formulation of functional foods and nutraceuticals against high blood pressure and oxidative stress. \u00a9 2016 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8112","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T16:49:23Z","timestamp":1482338963000},"page":"2834-2841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Inhibitory properties of bambara groundnut protein hydrolysate and peptide fractions against angiotensin\u2010converting enzymes, renin and free radicals"],"prefix":"10.1002","volume":"97","author":[{"given":"Abimbola K","family":"Arise","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Food Technology, Faculty of Applied Sciences Durban University of Technology, PO Box 1334  Durban 4001 South Africa"},{"name":"Department of Human Nutritional Sciences University of Manitoba  Winnipeg MB R3T 2 N2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeola 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