{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:15:50Z","timestamp":1784326550092,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Special Fund for Agro-scientific Research in the Public Interest of China","award":["201403047"],"award-info":[{"award-number":["201403047"]}]},{"name":"Zhejiang Provincial Key Science Project","award":["2015C03006"],"award-info":[{"award-number":["2015C03006"]}]},{"name":"Zhejiang Provincial Key Science Project","award":["2015C02G2010061"],"award-info":[{"award-number":["2015C02G2010061"]}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Plant extracts have been used widely to improve growth, lower cholesterol, and exert antioxidative defense and antimicrobial activities in animal production. The present study aimed to investigate the effects of dietary phytosterols (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) on growth performance, antioxidant enzymes and intestinal morphology in weaned piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 120 crossbred piglets, weighing 9.58 \u00b1 0.26 kg, were randomly allocated to three treatments: control, <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> (0.2 g kg<jats:sup>\u22121<\/jats:sup>) and polymyxin E (0.04 g kg<jats:sup>\u22121<\/jats:sup>, antibiotic control). Compared to the control, <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> or polymyxin E supplementation decreased diarrhea rate, serum cholesterol and malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>) of the piglets (<jats:italic>P<\/jats:italic> &lt; 0.05). Liver <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> was significantly decreased in <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>\u2010fed piglets compared to the control (<jats:italic>P<\/jats:italic> &lt; 0.05), although there was no difference between the control and polymyxin E\u2010fed piglets. <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> increased the villous height\/crypt depth ratio of the duodenum and jejunum compared to the control (<jats:italic>P<\/jats:italic> &lt; 0.05). Polymyxin E supplementation in piglets did not alter the villous height\/crypt depth ratio but raised the villous height and crypt depth of the duodenum compared to the control (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results of the present study indicated that <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> could decrease diarrhea rate, lower serum cholesterol, reduce lipid peroxidation and ameliorate intestinal morphology in weaned piglets. In addition, <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> exerted better amelioration on intestinal morphology than polymyxin E in piglets. \u00a9 2017 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8333","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T22:52:02Z","timestamp":1490655122000},"page":"4629-4634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Phytosterols on growth performance, antioxidant enzymes and intestinal morphology in weaned piglets"],"prefix":"10.1002","volume":"97","author":[{"given":"Qiaoling","family":"Hu","sequence":"first","affiliation":[{"name":"College of Animal Science, Zhejiang University Key Laboratory of Animal Feed and Nutrition of Zhejiang Province  PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University Key Laboratory of Animal Feed and Nutrition of Zhejiang Province  PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University Key Laboratory of Animal Feed and Nutrition of Zhejiang Province  PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Zhuo","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University Key Laboratory of Animal Feed and Nutrition of Zhejiang Province  PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-429X","authenticated-orcid":false,"given":"Jie","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University Key Laboratory of Animal Feed and Nutrition of Zhejiang Province  PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3382\/japr.2006-00116"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-008-0142-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2014-8244"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2006.04.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2012.03.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(12)60327-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(02)00006-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.22.020702.075220"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451400350X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.201100100"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2010.00107.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108112"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2014.10.014"},{"key":"e_1_2_7_15_1","volume-title":"EPC 2006 \u2013 12th European Poultry Conference","author":"Raeini\u2010Sarjaz M","year":"2006"},{"key":"e_1_2_7_16_1","first-page":"163","article-title":"Phytosterol supplementation improves antioxidant enzymes status and broiler meat quality","volume":"23","author":"Naji TA","year":"2013","journal-title":"Pak J Food Sci"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v13i1.2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.04.017"},{"key":"e_1_2_7_19_1","first-page":"58","article-title":"Effects of phytosterols on performance and blood biochemical parameters in weaned piglets","volume":"31","author":"Wei L","year":"2010","journal-title":"Acta Ecologiae Animalis Domastici"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1051\/animres:2004018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00081.2009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2014.09.005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2014.05.009"},{"key":"e_1_2_7_24_1","first-page":"9","article-title":"Analysis of IR, NMR and antimicrobial activity of \u03b2\u2010sitosterol isolated from Momordica charantia","volume":"1","author":"Sen A","year":"2013","journal-title":"Sci Secure J Biotechnol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2005.03.011"},{"key":"e_1_2_7_26_1","first-page":"1598","article-title":"Estimation of phytoconstituents from Cryptostegia grandiflora (Roxb.) 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