{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:36:38Z","timestamp":1790426198876,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Systolic blood pressure (SBP) of rats decreases significantly following exposure to the odor generated from the Maillard reaction of protein digests with xylose. This study identified active odorants that affect blood pressure and demonstrated the mechanism of action.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among the four potent odorants that contribute most to the odor of the Maillard reaction sample, 2,5\u2010dimethyl\u20104\u2010hydroxy\u20103(2<jats:italic>H<\/jats:italic>)\u2010furanone (DMHF) and 5\u2010methyl\u20102\u2010pyrazinemethanol (MPM) decreased SBP significantly. The earliest decrease in blood pressure was observed 5 min after exposure to DMHF. Application of zinc sulfate to the nasal cavity eliminated the effect. Furthermore, gastric vagal (parasympathetic) nerve activity was elevated and renal sympathetic nerve activity was lowered after exposure to DMHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>It is indicated that DMHF affects blood pressure through the olfactory system, and the mechanism for the effect of DMHF on blood pressure involves the autonomic nervous system. \u00a9 2017 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8538","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T06:30:21Z","timestamp":1499927421000},"page":"923-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Odors generated from the Maillard reaction affect autonomic nervous activity and decrease blood pressure through the olfactory system"],"prefix":"10.1002","volume":"98","author":[{"given":"Lanxi","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory of Food Function and Safety, Department of Animal Science, School of Veterinary Medicine Kitasato University  Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3969-150X","authenticated-orcid":false,"given":"Motoko","family":"Ohata","sequence":"additional","affiliation":[{"name":"Laboratory of Food Function and Safety, Department of Animal Science, School of Veterinary Medicine Kitasato University  Towada, Aomori Japan"},{"name":"Laboratory of Molecular Nutritional Science of Food, Department of Food Bioscience &amp; Biotechnology Nihon University  Fujisawa Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Owashi","sequence":"additional","affiliation":[{"name":"Laboratory of Food Function and Safety, Department of Animal Science, School of Veterinary Medicine Kitasato University  Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Nagai","sequence":"additional","affiliation":[{"name":"ANBAS Corporation Ltd  Kita\u2010ku, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Laboratory of Food Function and Safety, Department of Animal Science, School of Veterinary Medicine Kitasato University  Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Arihara","sequence":"additional","affiliation":[{"name":"Laboratory of Food Function and Safety, Department of Animal Science, School of Veterinary Medicine Kitasato University  Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92310-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.04.002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.06.031"},{"key":"e_1_2_5_5_1","first-page":"346","article-title":"The effects of grapefruit and yuzu flavored drinks on mood states and autonomic nervous system","volume":"60","author":"Takada K","year":"2014","journal-title":"Aroma Res"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450802333953"},{"key":"e_1_2_5_7_1","first-page":"46","volume-title":"Taste and Smell","author":"Gottfried JA","year":"2006"},{"key":"e_1_2_5_8_1","first-page":"21","article-title":"The effects of odor generated from protein digests and reducing sugar by the Maillard reaction on blood pressure","volume":"3","author":"Ohata M","year":"2014","journal-title":"IMARS Highlights"},{"key":"e_1_2_5_9_1","first-page":"161","volume-title":"Advances in Food and Nutrition Research","author":"Arihara K","year":"2017"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002170050486"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2012.02.007"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.05.007"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.7538"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90729-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41114"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.01.058"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.07.036"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.12.076"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0924-2244(93)90187-F"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1999.tb00187.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf8012025"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.10.008"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01546D"},{"issue":"1","key":"e_1_2_5_24_1","first-page":"5","article-title":"The role of vascular biology, nutrition and nutraceuticals in the prevention and treatment of hypertension","volume":"5","author":"Houston MC","year":"2002","journal-title":"J Am Nutraceut Assoc"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.68.1842"},{"key":"e_1_2_5_26_1","first-page":"261","volume-title":"Ganong's Review of Medical Physiology","author":"Barrett KE","year":"2009"}],"container-title":["Journal of the Science of Food and Agriculture"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjsfa.8538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsfa.8538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:37:39Z","timestamp":1760877459000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/jsfa.8538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jsfa.8538"],"URL":"https:\/\/doi.org\/10.1002\/jsfa.8538","archive":["Portico"],"relation":{},"ISSN":["0022-5142","1097-0010"],"issn-type":[{"value":"0022-5142","type":"print"},{"value":"1097-0010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]},"assertion":[{"value":"2017-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}