{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:12:35Z","timestamp":1779311555370,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31501431"],"award-info":[{"award-number":["31501431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Bioinformatics approaches are widely used to evaluate the prospects of novel protein sources in bioactive peptide research. Edible cyanobacteria are considered as potential protein precursors. However, the abundance of unicellular cyanobacterial proteins is largely unknown and highly dynamic according to the cultivation conditions, which need to be considered in this research field. The objective of this work was to evaluate the protein abundance of <jats:italic>Arthrospira platensis<\/jats:italic>, as well as to map the bioactive peptide sequences from the high\u2010abundance proteins of the <jats:styled-content style=\"fixed-case\"><jats:italic>A. platensis<\/jats:italic><\/jats:styled-content> proteome.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The high\u2010abundance proteins of the <jats:styled-content style=\"fixed-case\"><jats:italic>A. platensis<\/jats:italic><\/jats:styled-content> proteome were identified with a high\u2010performance liquid chromatography\u2013tandem mass spectrometry\u2010based method. A total of 593 proteins were detected and quantified. The occurrence frequency of the bioactive peptides in <jats:styled-content style=\"fixed-case\"><jats:italic>A. platensis<\/jats:italic><\/jats:styled-content> proteome was calculated according to the amino acid sequences via the bioinformatics approaches. Further <jats:italic>in silico<\/jats:italic> digested by trypsin, pepsin and chymotrypsin, these proteins liberated 78, 99, and 96 bioactive peptides, respectively. In each case, angiotensin\u2010converting enzyme inhibitors and dipeptidyl peptidase IV inhibitors were enriched.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This work will help rationally design the protocols for cyanobacterial cultivation, protein pre\u2010treatment and peptide separation, and further produce more peptides with specific functions. \u00a9 2017 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8546","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T11:36:36Z","timestamp":1500032196000},"page":"984-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Omics\u2010prediction of bioactive peptides from the edible cyanobacterium <i>Arthrospira platensis<\/i> proteome"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-4619","authenticated-orcid":false,"given":"Chaofan","family":"Ji","sequence":"first","affiliation":[{"name":"School of Food Science and Technology Dalian Polytechnic University  Dalian PR China"},{"name":"National Engineering Research Center of Seafood  Dalian PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology Dalian Polytechnic University  Dalian PR China"},{"name":"National Engineering Research Center of Seafood  Dalian PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology Dalian Polytechnic University  Dalian PR China"},{"name":"National Engineering Research Center of Seafood  Dalian PR 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