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The aim of this review is to summarise how these compounds can modulate the inflammatory pathways which characterise the most prevalent arthropathies including osteoarthritis, rheumatoid arthritis and crystal\u2010induced arthritis. Among polyphenols, epigallocatechin gallate, carnosol, hydroxytyrosol, curcumin, resveratrol, kaempferol and genistein have been the most widely investigated in arthritis. The most important results of the studies outlined in this article show how polyphenolic compounds are able to inhibit the expression and the release of a number of pro\u2010inflammatory mediators and proteolytic enzymes, the activity of different transcriptional factors and the production of reactive oxygen species in vitro. Studies on animal models of rheumatoid arthritis, osteoarthritis and gout show interesting results in terms of reduced tissue damage, restored cartilage homeostasis, and decreased levels of uric acid, respectively. Despite the multiple protective effects of polyphenols, there are no dietary recommendations for patients affected by rheumatic diseases. Future studies, including intervention trials, should be conducted to determine the relevance of polyphenols consumption or supplementation in arthritis. \u00a9 2017 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/jsfa.8664","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T12:08:40Z","timestamp":1504872520000},"page":"1653-1659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["Anti\u2010inflammatory effects of polyphenols in arthritis"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-5105","authenticated-orcid":false,"given":"Francesca","family":"Oliviero","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine \u2013 DIMED University of Padova  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Scanu","sequence":"additional","affiliation":[{"name":"Rheumatology 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