{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:07:05Z","timestamp":1761962825427,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Alcoholic hepatitis is a necroinflammatory process that is associated with fibrosis and leads to cirrhosis in 40% of cases. The hepatoprotective effects of red mold dioscorea (RMD) from <jats:italic>Monascus purpureus<\/jats:italic> NTU 568 were evaluated <jats:italic>in vivo<\/jats:italic> using a mouse model of chronic alcohol\u2010induced liver disease (ALD).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>ALD mice were orally administered vehicle (ALD group) or vehicle plus 307.5, 615.0 or 1537.5 mg kg<jats:sup>\u20131<\/jats:sup> (1 \u00d7, 2 \u00d7 and 5 \u00d7) RMD for 5 weeks. RMD lowered serum leptin, hepatic total cholesterol, free fatty acid and hepatic triglyceride levels and increased serum adiponectin, hepatic alcohol dehydrogenase and antioxidant enzyme levels. Furthermore, ankaflavin (AK) and monascin (MS), metabolites of RMD fermented with <jats:styled-content style=\"fixed-case\"><jats:italic>M. purpureus<\/jats:italic><\/jats:styled-content> 568, induced peroxisome proliferator\u2010activated receptor\u2010<jats:italic>\u03b3<\/jats:italic> expression and the concomitant suppression of ethanol\u2010induced elevation of sterol regulatory element\u2010binding transcription factor\u20101 and TG in HepG2 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>These results indicate the hepatoprotective effect of <jats:italic>Monascus<\/jats:italic>\u2010fermented RMD. Moreover, AK and MS were identified as the active constituents of RMD for the first time and were shown to protect against ethanol\u2010induced liver damage. \u00a9 2017 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.8670","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T11:16:41Z","timestamp":1505301401000},"page":"1889-1898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>Monascus<\/i>\u2010fermented red mold dioscorea protects mice against alcohol\u2010induced liver injury, whereas its metabolites ankaflavin and monascin regulate ethanol\u2010induced peroxisome proliferator\u2010activated receptor\u2010<i>\u03b3<\/i> and sterol regulatory element\u2010binding transcription factor\u20101 expression in HepG2 cells"],"prefix":"10.1002","volume":"98","author":[{"given":"Chih\u2010Fu","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Biochemical Science and Technology, College of Life Science National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-1893","authenticated-orcid":false,"given":"Tzu\u2010Ming","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biochemical Science and Technology, College of Life Science National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO Global Status Report on Alcohol and Health 2014. 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