{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:58:28Z","timestamp":1778691508008,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T00:00:00Z","timestamp":1528588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702129"],"award-info":[{"award-number":["31702129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Resveratrol has been shown to prevent high ambient temperature (HT)\u2010induced spleen dysplasia, but the mechanisms of action are not clear. This study aims to examine the hypothesis that HT\u2010induced spleen dysplasia may be associated with HT\u2010induced oxidative stress and apoptosis, and resveratrol may activate the nuclear factor erythroid 2\u2010related factor 2 (Nrf2) signaling pathway, thus reducing oxidative stress and apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Results showed that HT caused spleen dysplasia in broilers, reflecting the lower relative weight of the spleen (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Compared with birds in a normal ambient temperature group, birds in the HT group exhibited higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) malondialdehyde (MDA), protein carbonyl (PC), 8\u2010hydroxydeoxyguanosine (8\u2010OHdG) and Bcl\u20102 associated X protein (Bax) content, higher Bax, caspase\u20103 and caspase\u20109 mRNA levels, and caspase\u20103 and caspase\u20109 activity, and a higher Bax\/B\u2010cell lympoma\/leukemia\u20102 (Bcl\u20102) ratio, but they exhibited lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) glutathione (GSH) and Bcl\u20102 content, and lower Nrf2, glutathione peroxidase (Gpx), MnSOD, heme oxygenase 1, glutathione reductase (GR) and Bcl\u20102 mRNA levels, and lower total antioxidant capacity (T\u2010AOC), T\u2010SOD and catalase and maganese superoixide dismutase (CAT) activity, indicating HT\u2010induced oxidative stress and apoptosis. Compared with birds in the HT group, birds in the HT\u00a0+\u00a0Res group exhibited higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) GSH and Bcl\u20102 content, higher Nrf2, CAT, MnSOD, GR and Bcl\u20102 mRNA levels, and higher T\u2010AOC, T\u2010SOD and CAT activity, but lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) MDA content, and Bax and caspase\u20103 mRNA levels, lower caspase\u20103 and caspase\u20109 activities, and Bax\/Bcl\u20102 ratio, indicating that resveratrol activated the Nrf2 signaling pathway and decreased apoptosis in the spleen.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Resveratrol was effective in ameliorating HT\u2010induced spleen dysplasia in broilers through the activation of the Nrf2 signaling pathway, thereby decreasing apoptosis, suggesting that resveratrol may offer a potential nutritional strategy to protect against some HT\u2010induced detriments. \u00a9 2018 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.9084","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T03:46:13Z","timestamp":1524195973000},"page":"5409-5417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Protective effects of resveratrol against high ambient temperature\u2010induced spleen dysplasia in broilers through modulating splenic redox status and apoptosis"],"prefix":"10.1002","volume":"98","author":[{"given":"Cheng","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Anhui Agricultural University  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaikai","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Anhui Agricultural University  Hefei 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