{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:46:09Z","timestamp":1792824369215,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2019,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>This is the first study to investigate the therapeutic effects of <jats:italic>Cordyceps cicadae<\/jats:italic> (<jats:italic>C. cicadae)<\/jats:italic> mycelia and its active compound N<jats:sup>6<\/jats:sup>\u2010(2\u2010hydroxyethyl)adenosine (HEA) on blood glucose in genetically diabetic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Forty mice, 9 weeks of age, were divided into normal control, diabetic control, and three <jats:italic>C. cicadae<\/jats:italic> mycelia treated diabetic groups. After 9 weeks of continuous supplementation, the oral glucose tolerance test (OGTT) and homeostasis model of assessment\u2010insulin resistance index showed significant glucose tolerance with <jats:italic>C. cicadae<\/jats:italic> mycelia. Furthermore, the effect of HEA is similar to that of <jats:italic>C. cicadae<\/jats:italic> mycelia in an OGTT, suggesting that HEA could be the major factor responsible for the functional properties of <jats:italic>C. cicadae<\/jats:italic> mycelia.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Based on these findings, it is suggested that the therapeutic effect of <jats:italic>C. cicadae<\/jats:italic> mycelia may be driven by one of its active components, HEA, which could alleviate many diabetes complications in genetically obese mice and may offer promise as a supplement for diabetes management. \u00a9 2018 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.9221","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:49:40Z","timestamp":1530146980000},"page":"606-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Cordyceps cicadae<\/i> mycelia and its active compound HEA exert beneficial effects on blood glucose in type 2 diabetic db\/db mice"],"prefix":"10.1002","volume":"99","author":[{"given":"I\u2010Chen","family":"Li","sequence":"first","affiliation":[{"name":"Grape King Bio Ltd  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lin","sequence":"additional","affiliation":[{"name":"Grape King Bio Ltd  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh\u2010Ting","family":"Tsai","sequence":"additional","affiliation":[{"name":"Testing Center, Super Laboratory Inc.  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