{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:40:41Z","timestamp":1760920841422,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Curry powder is a blend of spices that is extensively consumed worldwide and mainly in Central Asia. Its preparation is strictly related to each locality and, because of the health benefits of its constituents, eight commercial forms of this condiment were biologically and chemically investigated. This study aimed to compare their chemical profile as well as their anti\u2010inflammatory, cytotoxic, and antiparasitic activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Curry samples <jats:bold>1<\/jats:bold> and <jats:bold>7<\/jats:bold> inhibited leukocyte influx and myeloperoxidase activity, while only <jats:bold>7<\/jats:bold> was active on protein exudate and NO<jats:sub><jats:italic>x<\/jats:italic><\/jats:sub> species. <jats:bold>2<\/jats:bold>, <jats:bold>6<\/jats:bold>, and <jats:bold>8<\/jats:bold> displayed trypanocidal effect against <jats:italic>Trypanosoma cruzi<\/jats:italic> amastigote, whereas <jats:bold>6<\/jats:bold> showed antileishmanial activity on <jats:italic>Leishmania amazonensis<\/jats:italic> amastigote. <jats:bold>2<\/jats:bold>, <jats:bold>6<\/jats:bold>, and <jats:bold>8<\/jats:bold> also inhibited the growth of THP\u20101 cells used as the parasite's host. Among the cytotoxic samples (<jats:bold>4<\/jats:bold> and <jats:bold>6<\/jats:bold>), curry sample <jats:bold>6<\/jats:bold> induced apoptosis in MDA\u2010MB\u2010231 cells. Nevertheless, <jats:bold>4<\/jats:bold> and <jats:bold>6<\/jats:bold> were unselectively cytotoxic to non\u2010tumoral and tumoral cells. The anti\u2010inflammatory, cytotoxicity, and antiparasitic assays were respectively performed by carrageenan\u2010induced pleurisy test, Alamar blue assay, and intracellular parasite\u2013host cell model. Ultra\u2010performance liquid chromatographic\u2013electrospray ionization mass spectrometric data from the spices revealed both similar and different metabolites in their composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The results obtained indicate that different formulations can contribute different health benefits as a result of their chemical composition. \u00a9 2018 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.9512","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T02:28:56Z","timestamp":1543285736000},"page":"2987-2997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytotoxicity, antiprotozoal, and anti\u2010inflammatory activities of eight curry powders and comparison of their UPLC\u2010ESI\u2010QTOF\u2010MS chemical profiles"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-7733","authenticated-orcid":false,"given":"Louis P","family":"Sandjo","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Zingue","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"},{"name":"Department of Live and Earth Sciences, Higher Teachers' Training College University of Maroua  Maroua Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus VP","family":"dos Santos Nascimento","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milene H","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geison","family":"Vicente","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon KS","family":"Amoah","sequence":"additional","affiliation":[{"name":"Metrology Department Instituto SENAI de Tecnologia em Alimentos e Bebidas  Chapeco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo M","family":"Dalmarco","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania S","family":"Frode","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, Centre of Health Sciences Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e2nia B","family":"Creczynski\u2010Pasa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Steindel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology Universidade Federal de Santa Catarina  Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0015732515660207"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc5502_2"},{"key":"e_1_2_6_4_1","unstructured":"MercolaJ Why curry will surprise you. 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