{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:56:43Z","timestamp":1787590603547,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2019JJ50268"],"award-info":[{"award-number":["2019JJ50268"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Nucleotides are key constituents of milk, where they are utilized in cell replication, although there are limited studies for weaned piglets. This study evaluated the effects of uridine monophosphate (UMP) with uridine (UR) feed supplementation on the intestinal development and nucleotide transport in weaned piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Supplementation with UMP significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) plasma glucose, and UR supplementation significantly reduced (0.05\u2009&lt;\u2009<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.10) the plasma total cholesterol (TC) of piglets when compared with that of the control group, although non\u2010significant difference (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) in growth performance was observed among three groups. Piglets fed supplementary UR exhibited greater (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) crypt depth in the duodenum and ileum when compared with those in the supplementary UMP and control groups. Real\u2010time quantitative polymerase chain reaction (RT\u2010qPCR) results revealed that UR supplementation increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the relative mRNA levels of genes encoding the transmembrane proteins ZO\u20101 and occludin in the duodenum mucosa, and ZO\u20101 in the jejunum mucosa (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Similarly, UR supplementation increased (<jats:italic>P<\/jats:italic> &lt; 0.05) expression of solute carriers SLC28A1 and SLC29A1 in the duodenum mucosa. Conversely, claudin\u20101 expression in the duodenum mucosa was inhibited (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) by dietary supplementation with UMP or UR.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Collectively, our data indicated that dietary supplementation with UMP or UR was conducive to stimulating intestinal development and promoting nucleotide transport in weaned piglets. \u00a9 2019 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.9850","type":"journal-article","created":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T02:19:18Z","timestamp":1560046758000},"page":"6108-6113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate intestinal development and promote nucleotide transport in weaned piglets"],"prefix":"10.1002","volume":"99","author":[{"given":"Chun\u2010yan","family":"Xie","sequence":"first","affiliation":[{"name":"College of Bioscience and Biotechnology Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agro\u2010ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; 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