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Antioxidants used against sepsis have been evaluated, including essential oils such as <jats:italic>\u03b2<\/jats:italic>\u2010caryophyllene (BCP), and polyunsaturated fatty acids, such as docosahexaenoic acid (DHA). The aim of this study was to evaluate the anti\u2010inflammatory activity of the association of these two compounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Treatment with BCP\u2010DHA, at a dose of 200\u2009\u03bcL\/animal, significantly inhibited the migration of neutrophils in a Cg\u2010induced peritonitis model. After <jats:italic>Staphylococcus aureus<\/jats:italic> infection, in the groups treated with BCP\u2010DHA there was a significant decrease in the total and differential count of leukocytes, increased expression of cytokines TNF\u2010<jats:italic>\u03b1<\/jats:italic> and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in treated groups, an increase of IL\u20104 and IL\u20105 in B\/D and B\/D\u2009+\u2009SA groups, and an augmentation of IL\u20106 and IL\u201012 groups in B\/D\u2009+\u2009SA groups. Histological and bacterial analysis revealed lower neutrophil migration and lower bacterial load in the infected and treated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In general, the BCP\u2010DHA association presented anti\u2010inflammatory activity against two different models of acute inflammation and infection, showing promising potential as a therapeutic adjuvant in sepsis. \u00a9 2019 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.9861","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T13:07:01Z","timestamp":1560776821000},"page":"5870-5880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Anti\u2010inflammatory activity of <i>\u03b2<\/i>\u2010caryophyllene combined with docosahexaenoic acid in a model of sepsis induced by <i>Staphylococcus aureus<\/i> in 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