{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:20:30Z","timestamp":1789147230808,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003121","name":"Ferdowsi University of Mashhad","doi-asserted-by":"publisher","award":["39205"],"award-info":[{"award-number":["39205"]}],"id":[{"id":"10.13039\/501100003121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Traditional fermented products are a rich source of microorganisms which may have remarkable probiotic properties even more significant than probiotic strains of human origin. In this study three <jats:italic>Lactobacillus plantarum<\/jats:italic> and one <jats:italic>Lactobacillus fermentum<\/jats:italic> strains, isolated from either Iranian traditionally fermented products or children's feces, identified with molecular methods and selected based on high acid resistance, were investigated for their probiotic properties <jats:italic>in vitro<\/jats:italic> and compared with standard probiotic strains of the species; <jats:italic>L. plantarum<\/jats:italic> ATCC 14917, <jats:italic>L. fermentum<\/jats:italic> PTCC 1744 and <jats:italic>L. acidophilus<\/jats:italic> ATCC 4356.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Most of the isolates showed a high survival rate under gastrointestinal tract conditions and <jats:italic>L. plantarum<\/jats:italic> strains displayed a moderate ability to adhere to human colon adenocarcinoma cell line, HT\u201029. Neutralized cell free culture supernatants of <jats:italic>L. plantarum<\/jats:italic> strains were capable of inhibiting pathogens. Almost all of the strains were resistant to vancomycin and streptomycin and susceptible to other clinically relevant antibiotics. Isolated strains exhibited low to moderate autoaggregation (Auto\u2010A), co\u2010aggregation (Co\u2010A) and hydrophobicity, following a strain specific manner. None of the strains invaded into HT\u201029 cells while strain PF11 could significantly decrease the number of adhering pathogenic bacteria. Most of the strains increased apoptosis of HT\u201029 cells, though they had no effect on human umbilical vein endothelial cells (HUVECs).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Favorable probiotic properties of strains PL4 and PF11 along with their anticancer activity imply their potential for clinical or technological applications. However, further <jats:italic>in vitro<\/jats:italic>\/<jats:italic>in vivo<\/jats:italic> investigations are recommended. \u00a9 2019 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.9945","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T04:13:52Z","timestamp":1563768832000},"page":"6680-6688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Probiotic potential comparison of <i>Lactobacillus<\/i> strains isolated from Iranian traditional food products and human feces with standard probiotic strains"],"prefix":"10.1002","volume":"99","author":[{"given":"Mehri","family":"Joghataei","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Agriculture Ferdowsi University of Mashhad  Mashhad 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