{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:57:24Z","timestamp":1785772644375,"version":"3.56.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Sci Food Agric"],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Oyster polypeptides have various biofunctions, such as anti\u2010cancer and anti\u2010oxidative stress, but whether it has the protective effects to primary ovarian failure (POF) remains poorly understand. To address this issue, daily gavage of oyster polypeptides was performed to investigate their protective effect, basing on <jats:sc>d<\/jats:sc>\u2010galactose\u2010induced POF model in C57BL\/6 female mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Oyster polypeptides restored the irregular estrous cycles and the abnormal serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and progesterone (P) levels as well as the decreased mRNA expression level of <jats:italic>Amh<\/jats:italic> that were induced by <jats:sc>d<\/jats:sc>\u2010galactose. The follicle development of POF mice was improved by increasing the primordial follicle ratio and decreasing the atretic follicle number after oral administration of oyster polypeptides. Moreover, in the oyster polypeptides treated mice, the total superoxide dismutase (T\u2010SOD) activity was significantly increased, while the malondialdehyde levels were significantly decreased. The mRNA expression levels of stress\u2010related genes (<jats:italic>SOD2<\/jats:italic>, <jats:italic>SIRT1<\/jats:italic> and <jats:italic>FOXO3a<\/jats:italic>) were remarkably up\u2010regulated after <jats:sc>d<\/jats:sc>\u2010galactose induction, but the up\u2010regulation was weakened or disappeared by the gavage of oyster polypeptides. In addition, oyster polypeptides treatment also reduced the apoptosis of the ovarian granulosa cells and down\u2010regulated the mRNA expression levels of apoptosis\u2010related genes (<jats:italic>p53<\/jats:italic> and <jats:italic>Bad<\/jats:italic> but not <jats:italic>Bcl\u20102<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This study reveals that oyster polypeptides may protect ovary against <jats:sc>d<\/jats:sc>\u2010galactose\u2010induced POF by their anti\u2010oxidative stress activity to rescue <jats:sc>d<\/jats:sc>\u2010galactose\u2010induced ovarian oxidative damage and therefore to prevent ovarian cells apoptosis, thereby tipping the abnormality trigged by POF to get close to the normal levels. \u00a9 2019 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/jsfa.9997","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T04:20:01Z","timestamp":1566447601000},"page":"92-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Oral oyster polypeptides protect ovary against <scp>d<\/scp>\u2010galactose\u2010induced premature ovarian failure in C57BL\/6 mice"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4774-5969","authenticated-orcid":false,"given":"Yunkun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Engineering and Applied Biology College of Life Science, Sichuan Agricultural University  Ya'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Engineering and Applied Biology College of Life Science, Sichuan Agricultural 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