{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:06:35Z","timestamp":1777529195279,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,5,16]],"date-time":"2002-05-16T00:00:00Z","timestamp":1021507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a lack of appropriate information in regard to the optimal treatment for colon cancer infiltrating neighboring organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study is to analyze treatment results and to identify the risk factors of death by cancer in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 40 patients with colon cancer infiltrating neighboring organs without distant metastases was carried out. Patterns of recurrence and 5\u2010year survival were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 20 males and 20 females with a median age of 51.5 years. Primary tumor location was as follows: right colon (n\u2009=\u200915); transverse colon (n\u2009=\u20095); left colon (n\u2009=\u20097), and sigmoid (n\u2009=\u200913). In 17 patients, the colon tumor infiltrated the abdominal wall alone or together with neighboring organs and in 23 patients, one or more neighboring organs were infiltrated. Eleven patients (27.5%) developed postoperative complications. Two patients (5%) died during the postoperative period. Microscopic tumor infiltration was demonstrated in 29 patients (72.5%). Tumor stage was as follows: T3,N0 (n\u2009=\u20098); T3,N+ (n\u2009=\u20093); T4,N0 (n\u2009=\u200916), and T4,N+ (n\u2009=\u200913). Overall 5\u2010year survival was 45%. Multivariate analysis shows that the unfavorable risk factors for 5\u2010year survival were neoplastic cell infiltration to neighboring organs, age &gt;\u200950 years, and lymph node metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The main risk factors for cancer\u2010related failure are neoplastic infiltration to neighboring organs, age &gt;\u200950 years, and lymph node metastases. In T4 colon cancer, the recurrence pattern was found at local, peritoneal, and distant sites. J. Surg. 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