{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T05:07:45Z","timestamp":1700284065252},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,5,22]],"date-time":"2003-05-22T00:00:00Z","timestamp":1053561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>B\u2010cell MALT lymphoma is a well\u2010recognized entity and its characterization as low\u2010grade (LG) and high\u2010grade (HG) lymphoma has been widely accepted. In the present study we reviewed a series of 95 surgical specimens of primary gastric MALT lymphoma selected between 1979 and 1998. Immunohistochemical expression of p53, bcl\u20102, and Ki67 and <jats:italic>Helicobacter pylori<\/jats:italic> (Hp) infection was evaluated, along with a correlation with clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A morphologic and immunohistochemical analysis, including p53, bcl\u20102, and Ki67 expression, was carried out in all cases. A complete follow\u2010up was obtained in 49 patients and in these cases a survival analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>bcl\u20102 protein was highly expressed in 25 of 25 assessed LG tumors and in 20 of 24 assessed HG tumors. p53 protein was expressed in 13 of 25 assessed LG tumors and in 21 of 24 assessed HG tumors. High proliferation rate as expressed by Ki67 was detected in 15 of 25 assessed LG tumors and in 23 of 24 assessed HG tumors. Hp infection was detected in 11 of 16 assessed LG tumors and 2 of 10 assessed HG tumors. Median survival rates were 72 months for LG tumors and 24 months for HG tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant inverse relationship between Hp infection and histological grade was found. High p53 expression and high\u2010proliferation rate correlated with HG tumors. However, a correlation between p53, bcl\u20102, and Ki67 expression with clinical outcome was not found. J. Surg. Oncol. 2003;83:106\u2013111. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.10241","type":"journal-article","created":{"date-parts":[[2003,5,23]],"date-time":"2003-05-23T10:02:15Z","timestamp":1053684135000},"page":"106-111","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathologic and immunohistochemical study of surgically treated primary gastric MALT lymphoma"],"prefix":"10.1002","volume":"83","author":[{"given":"Luigi","family":"Insabato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Di Vizio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Tornillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco P.","family":"D'Armiento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Siciliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Milo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Pettinato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi M.","family":"Terracciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.5.395"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.5450786.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90130-Z"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00597.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199801000-00003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90063-Q"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70026-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90838-G"},{"key":"e_1_2_1_12_2","first-page":"989","article-title":"Different bcl\u20102 protein expression in high grade B\u2010cell lymphomas derived from lymph node or mucosa\u2010associated lymphoid tissue","volume":"139","author":"Villuendes R","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00624.x"},{"key":"e_1_2_1_14_2","first-page":"1327","article-title":"Follicular lymphomas of the gastrointestinal tract: Pathologic features in 31 cases and bcl\u20102 oncogenic protein expression","volume":"140","author":"Le Brun DP","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.1.18"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199604)178:4<379::AID-PATH487>3.0.CO;2-J"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.d01-573.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90061-1"},{"key":"e_1_2_1_19_2","first-page":"503","article-title":"Primary gastric lymphomas. Clinicopathological study and evaluation of prognostic factors in 65 surgically treated cases","volume":"92","author":"Pozzi B","year":"2000","journal-title":"Pathologica"},{"key":"e_1_2_1_20_2","first-page":"245","article-title":"P53 in lymphomas of mucosal associated lymphoid tissue","volume":"9","author":"Levy V","year":"1996","journal-title":"Mod Pathol"},{"key":"e_1_2_1_21_2","first-page":"218","article-title":"Klinische: Stadieneinteilung der nicht. Hodgkin lymphome","volume":"153","author":"Musshoff K","year":"1997","journal-title":"Sonderb Z Strahlenther Onkol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711520407"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711540305"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199600001-00002"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.5.436"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265829249"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.4.471"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800821025"},{"key":"e_1_2_1_31_2","first-page":"790","article-title":"p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma","volume":"147","author":"Bosari S","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.7262"},{"key":"e_1_2_1_33_2","first-page":"1","article-title":"Heterogeneity of sub\u2010cellular localization of p53 protein in human glioblastomas","volume":"54","author":"Ali IU","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.10.4407"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1996.tb03664.x"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.10241","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.10241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:47:10Z","timestamp":1700268430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.10241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,22]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1002\/jso.10241"],"URL":"https:\/\/doi.org\/10.1002\/jso.10241","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5,22]]}}}