{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:26:29Z","timestamp":1768703189283,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,5,22]],"date-time":"2003-05-22T00:00:00Z","timestamp":1053561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Apolipoprotein D (Apo D) is a protein component of the human plasma lipid transport system, and an androgen\u2010regulated protein in both breast and prostate cancer cell lines. Our goal was to evaluate the expression of Apo D in malignant cutaneous melanomas, as well as to assess its possible relationship to clinical and pathological parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Apo D expression was analyzed in 32 paraffin\u2010embedded tissues from patients with invasive cutaneous malignant melanomas, in 8 samples from in situ melanoma, and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi, and 2 dysplastic melanocytic nevi), using immunohistochemical techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The benign lesions were consistently negative for Apo D, whereas 3 of the 8 \u201cin situ\u201d melanomas (37.5%) and 12 of the 32 invasive melanomas (37.5%) showed positive immunostaining for Apo D. The percentage of Apo D\u2010positive tumors was significantly higher in nodular than in superficial spreading melanomas (<jats:italic>P<\/jats:italic>\u2009=\u20090.011) and in melanomas with vertical growth phase than in melanomas with radial growth phase (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). In addition, the percentage of Apo D\u2010positive tumors was positively and significantly correlated with Clark's level of invasion (<jats:italic>P<\/jats:italic>\u2009=\u20090.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Apo D may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma. J. Surg. Oncol. 2003;83:99\u2013105. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.10245","type":"journal-article","created":{"date-parts":[[2003,5,23]],"date-time":"2003-05-23T10:02:15Z","timestamp":1053684135000},"page":"99-105","source":"Crossref","is-referenced-by-count":19,"title":["Apolipoprotein D expression in cutaneous malignant melanoma"],"prefix":"10.1002","volume":"83","author":[{"given":"Eva","family":"Miranda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Vizoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arancha","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Quintela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda 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