{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:05:48Z","timestamp":1760295948786},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,3,21]],"date-time":"2001-03-21T00:00:00Z","timestamp":985132800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objects<\/jats:title><jats:p>Matrix degradation, which is a critical event in the process of tumor invasion and metastasis, is considered to be caused by the action of proteolytic enzymes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the gelatinolytic activity of matrix metalloproteinase (MMP)\u20109, and the activity of active and inactive forms of MMP\u20102 in five thymi, five noninvasive thymomas, eight invasive thymomas, and five thymic carcinomas by quantitative gelatinolytic zymography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The gelatinolytic activity of active MMP\u20102 in five thymi was zero. The mean gelatinolytic activity of active MMP\u20102 was 0.020\u2009\u00b1\u20090.015 in noninvasive thymoma, 0.084\u2009\u00b1\u20090.098 in invasive thymoma and 0.246\u2009\u00b1\u20090.194 in thymic carcinoma. The gelatinolytic activity of active MMP\u20102 correlated with the invasiveness of thymic epithelial tumors (Spearman rank correlation: <jats:italic>r<\/jats:italic>\u2010value\u2009=\u20090.532). The gelatinolytic activity of active MMP\u20102 in three thymoma cases with microscopic capsular invasion was the same as that of noninvasive thymoma. When thymoma cases showing microscopic capsular invasion were classified into the \u201cmacroscopically noninvasive thymoma\u201d group, the gelatinolytic activity of active MMP\u20102 correlated with the invasiveness of thymic epithelial tumors (Spearman rank correlation: <jats:italic>r<\/jats:italic>\u2010value\u2009=\u20090.621).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The gelatinolytic activity of active MMP\u20102 significantly correlated with the invasiveness in thymic epithelial tumors. <jats:italic>J. Surg. Oncol.<\/jats:italic> 2001;76:169\u2013175. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.1030","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:27:27Z","timestamp":1030310847000},"page":"169-175","source":"Crossref","is-referenced-by-count":15,"title":["Activation of matrix metalloproteinase\u20102 is correlated with invasiveness in thymic epithelial tumors"],"prefix":"10.1002","volume":"76","author":[{"given":"Kazuya","family":"Kondo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Ishikura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumichi","family":"Matsumori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Monden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,3,21]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"40","volume-title":"Atlas of tumor pathology. 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