{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:09:02Z","timestamp":1790503742693,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,11,24]],"date-time":"2003-11-24T00:00:00Z","timestamp":1069632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Tumor\u2010infiltrating lymphocytes form an important aspect of the host defense against an expanding neoplasm. CD8<jats:sup>+<\/jats:sup> T cells have been identified as a prognostic factor in several cancers. Here, we investigate that the influence of CD8<jats:sup>+<\/jats:sup> T cells on extrahepatic bile duct carcinoma (EBDC) patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CD8<jats:sup>+<\/jats:sup> T cell immunoreactivity in 58 surgically resected EBDC specimens was investigated. The relationship between CD8<jats:sup>+<\/jats:sup> T cell immunoreactivity and clinical and histopathologic features was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two tumors (55%) possessed intratumoral CD8<jats:sup>+<\/jats:sup> T cells. The degree of intratumoral CD8<jats:sup>+<\/jats:sup> T cell immunoreactivity demonstrated a significant relationship to lower numbers of lymph node metastasis, reduced venous invasion, decreased perineural invasion, and better pTNM staging. Intratumoral CD8<jats:sup>+<\/jats:sup> T cells were also associated with increased patient survival. Multivariate analysis indicated that the presence of intratumoral CD8<jats:sup>+<\/jats:sup> T cells was an independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The infiltration of a cancer cell nest by CD8<jats:sup>+<\/jats:sup> T cells is a reliable marker predicting increased survival of patients with EBDC. J. Surg. Oncol. 2003;84:224\u2013228. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.10321","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T14:30:42Z","timestamp":1070375442000},"page":"224-228","source":"Crossref","is-referenced-by-count":90,"title":["Prognostic value of intratumoral CD8<sup>+<\/sup> T lymphocyte in extrahepatic bile duct carcinoma as essential immune 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