{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:35:04Z","timestamp":1770824104632,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,23]],"date-time":"2004-02-23T00:00:00Z","timestamp":1077494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent data indicates that the sentinel lymph node biopsy (SLNB) is a possible alternative to axillary lymph node dissection (ALND) in early breast cancer patients, with minimal risk of complications.<\/jats:p><jats:p>From the medical oncologist's point of view, the impact of SLNB on the management of patients should consider if SLNB is useful to choose adjuvant treatment, if it is adequate to provide local control, and what is the significance of lymph node micrometastases on treatment and staging. Lymph node involvement has always been recognised as the most important prognostic factor in early\u2010stage breast cancer, even if many other parameters have been evaluated in recent years. However, the lack of knowledge of nodal status in patients with false\u2010negative SLNB seems to result in an undertreatment in a very low percentage of patients. Adjuvant chemotherapy and hormonal therapy with tamoxifen are associated with an absolute reduction of the risk of recurrence and death both in node\u2010positive and in node\u2010negative patients, then if patients are treated with modern adjuvant systemic therapy, any effect associated with false negative SLN should be minimised.<\/jats:p><jats:p>The impact of axillary treatment on survival is still controversial, but in recent times axillary lymph node positivity is considered as an indicator for high risk of systemic diffusion of the disease rather than a possible origin of systemic metastases.<\/jats:p><jats:p>The significance of occult sentinel lymph node metastases detected by immunohistochemistry (IHC) or molecular biology on prognosis is still uncertain. The new version of the staging system of breast cancer has recognised the need for a standard diagnostic approach and of a nomenclature system which also takes SLNB into account. J. Surg. Oncol. 2004;85:129\u2013132. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.20025","type":"journal-article","created":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T20:38:05Z","timestamp":1077827885000},"page":"129-132","source":"Crossref","is-referenced-by-count":12,"title":["Sentinel lymph node biopsy in breast cancer patients: The medical oncology perspective"],"prefix":"10.1002","volume":"85","author":[{"given":"Tiziana","family":"Catzeddu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfilippo","family":"Bertelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Del Mastro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,23]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Il cancro in Italia. I dati di incidenza dei Registri Tumori","author":"Zanetti R","year":"1998"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089169808400305"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01004-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391401"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2345"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391410"},{"key":"e_1_2_1_9_2","first-page":"966","article-title":"College of American Pathologists Consensus Statement 1999","volume":"26","author":"Fitzgibbons PL","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.18.3817"},{"key":"e_1_2_1_11_2","first-page":"42","article-title":"Adjuvant chemotherapy for breast cancer","volume":"36","author":"National Institutes of Health Consensus Development Conference Statement","year":"1986","journal-title":"CA Cancer J Clin"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008339331020"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.018"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.944"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020128"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371402"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371401"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11423-4"},{"key":"e_1_2_1_19_2","first-page":"394","article-title":"Histopathologic validation of the sentinel lymph node hypothesis for breast carcinoma","volume":"222","author":"Turner RR","year":"1995","journal-title":"Ann Surg"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981218)79:6<645::AID-IJC16>3.0.CO;2-R"},{"key":"e_1_2_1_21_2","first-page":"37a","article-title":"Occult\/micrometastases in axillary lymph nodes of breast cancer patients ar significant: A retrospective study with long\u2010term follow up","volume":"21","author":"Tan LK","year":"2002","journal-title":"Proc ASCO"},{"key":"e_1_2_1_22_2","first-page":"24a","article-title":"Clinical significance of axillary micrometastases in breast cancer: How small is too small?","volume":"20","author":"Hansen NM","year":"2001","journal-title":"Proc ASCO"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.026"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10539"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021967"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.20025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.20025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.20025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T23:21:44Z","timestamp":1700176904000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.20025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,23]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1002\/jso.20025"],"URL":"https:\/\/doi.org\/10.1002\/jso.20025","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,23]]}}}