{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:44:15Z","timestamp":1773773055204,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T00:00:00Z","timestamp":1134432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The regional lymph node basin is usually the first site of spread in cutaneous squamous cell carcinoma (SCC). Regional metastases are usually treated with comprehensive nodal dissection, sometimes followed by radiation and\/or chemotherapy. Occasionally, when disease recurs after these conventional therapies, major extremity amputation may be the only way to render patients free of disease. We present three cases for which major extremity amputation was necessary. One patient underwent forequarter amputation for nodal metastasis, which had invaded the brachial plexus. Another patient underwent hip disarticulation for femoral bony invasion from inguinal nodal metastasis. The third patient underwent a hemipelvectomy for nodal metastasis, which had eroded the femoral artery and pelvic bone. These cases show that major extremity amputation can be both palliative and curative in patients with SCC. J. Surg. Oncol. 2006;93:76\u201378. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.20347","type":"journal-article","created":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T20:18:38Z","timestamp":1134505118000},"page":"76-78","source":"Crossref","is-referenced-by-count":7,"title":["Major extremity amputation for nodal metastasis from squamous cell carcinoma"],"prefix":"10.1002","volume":"93","author":[{"given":"Elizabeth A.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukes P.","family":"Namm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.01169.x"},{"key":"e_1_2_1_3_2","first-page":"311","article-title":"Metastases from squamous cell carcinoma of the skin","volume":"86","author":"Wilson SM","year":"1990","journal-title":"J South Carolina Med Assoc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850615)55:12<2862::AID-CNCR2820551226>3.0.CO;2-H"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198208000-00005"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.5.582"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.155"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)44281-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930470212"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2106\/00004623-195638020-00001","article-title":"Major exarticulations for malignant neoplasms of the extremities: Interscapulothoracic amputation, hip\u2010joint disarticulation, and interilio\u2010abdominal amputation; a report of end results in 228 cases","volume":"38","author":"Pack GT","year":"1956","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_1_11_2","first-page":"381","article-title":"Evaluation of forequarter amputation in malignant diseases","volume":"142","author":"Fanous N","year":"1976","journal-title":"Surgery Gynecology and Obstetrics"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90085-W"},{"key":"e_1_2_1_13_2","first-page":"99","article-title":"Hemipelvectomy: A changing perspective for a rare procedure","volume":"47","author":"Baliski CR","year":"2004","journal-title":"Can J Surg"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)60319-7"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.20347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T15:35:48Z","timestamp":1700062548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.20347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,13]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/jso.20347"],"URL":"https:\/\/doi.org\/10.1002\/jso.20347","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,13]]}}}