{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:54:36Z","timestamp":1791474876097,"version":"4.3.4"},"reference-count":92,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of esophageal adenocarcinoma has risen rapidly over the past 25 years in the United States as well as in several Western European countries. This increase had been most dramatic among white males. The majority of these cancers arise from a background of premalignant Barrett esophagus. However, less than 10% of the patients with esophageal adenocarcinoma were known to have Barrett esophagus previously. It is uncertain which risk factors contribute to the increasing incidence of esophageal adenocarcinoma, although gastroesophageal reflux disease, cigarette smoking, and obesity have been implicated. Whereas infection with <jats:italic>Helicobacter pylori<\/jats:italic> and use of non\u2010steroidal anti\u2010inflammatory drugs are associated with reduced risk, low intakes of fruit, vegetables, and cereal fibers seem to increase the risk of esophageal adenocarcinoma. Presently there is no evidence that strongly supports any specific strategy to screen a subgroup of the population at risk for Barrett esophagus and adenocarcinoma of the esophagus. J. Surg. Oncol. 2005;92:151\u2013159. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.20357","type":"journal-article","created":{"date-parts":[[2005,11,19]],"date-time":"2005-11-19T02:47:00Z","timestamp":1132368420000},"page":"151-159","source":"Crossref","is-referenced-by-count":239,"title":["Epidemiology of esophageal adenocarcinoma"],"prefix":"10.1002","volume":"92","author":[{"given":"Manuel","family":"Pera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Manterola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Grande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197904)43:4<1557::AID-CNCR2820430450>3.0.CO;2-L"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1955.01270110034006"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196811)22:5<915::AID-CNCR2820220503>3.0.CO;2-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800650709"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420100022004"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1995.01430060055011"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90990-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)01387-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70187-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1001\/jama.1993.03510110056031","article-title":"Continuing climb in rates of esophageal adenocarcinoma: An update [letter]","volume":"270","author":"Blot WJ","year":"1993","journal-title":"JAMA"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540309"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90420-H"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<612::AID-CNCR2820610332>3.0.CO;2-Q"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(02)00002-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10940"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.265.22.2960b"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199202000-00009"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199204000-00008"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10721"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010414"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10427"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.4.645"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930715)72:2<330::AID-CNCR2820720205>3.0.CO;2-L"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.314"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji024"},{"key":"e_1_2_1_29_2","first-page":"A82","article-title":"Prevalence of Barrett's esophagus and intestinal metaplasia at the esophagogastric junction","volume":"112","author":"Cameron AJ","year":"1997","journal-title":"Gastroenterology"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0016-5085(84)80016-5","article-title":"Clinical epidemiologic and morphologic comparison between adenocarcinomas arising in Barrett's esophageal mucosa and gastric cardia","volume":"86","author":"Kalish RJ","year":"1984","journal-title":"Gastroenterology"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198612000-00004"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80038-7"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10420"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11029"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1001\/jama.1995.03530060048032","article-title":"The relation of gastroesophageal reflux disease and its treatment to adenocarcinoma of the esophagus and gastric cardia","volume":"274","author":"Chow WH","year":"1995","journal-title":"JAMA"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.6.754"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008913828105"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70308-3"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9302"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-3-200302040-00009"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.agast960614"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)22922-1"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.304"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63269-2"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40187.x"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90607-3"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010420"},{"key":"e_1_2_1_50_2","first-page":"212","article-title":"The incidence of adenocarcinoma in Barrett's esophagus: A prospective study of 170 patients followed 4.8 years","volume":"92","author":"Drewitz DJ","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.5"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01276.x"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9849"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00776.x"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199801000-00004"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.11.1454"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480309"},{"key":"e_1_2_1_58_2","first-page":"779","article-title":"Association of adenocarcinoma and squamous cell carcinoma of the esophagus with tobacco\u2010related and other malignancies","volume":"6","author":"Ahsan H","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg047"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.17.1277"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<340::AID-IJC8>3.0.CO;2-N"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930815)72:4<1155::AID-CNCR2820720404>3.0.CO;2-C"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb02135.x"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011290704728"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635589709514541"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.8.961"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-998-0305-8"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.3.466"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20529"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000016573.79453.ba"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.2.150"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.2.104"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.1.137"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.11.3467S"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC421_5"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21171"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1121"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(97)00060-2"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000901)87:5<750::AID-IJC19>3.0.CO;2-6"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC382_7"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.10.750"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.1.80"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-3-200008010-00007"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-3-200008010-00016"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50008"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951001)76:7<1116::AID-CNCR2820760703>3.0.CO;2-I"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-03-0198"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh039"},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70422-6"},{"key":"e_1_2_1_90_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297"},{"key":"e_1_2_1_91_2","first-page":"588","article-title":"An inverse relation between cagA strains of Helicobacter pylory infection and risk of esophageal and gastric cardia adenocarcinoma","volume":"58","author":"Chow W","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_1_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10887"},{"key":"e_1_2_1_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh057"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.20357","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.20357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:54:31Z","timestamp":1694508871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.20357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,18]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1002\/jso.20357"],"URL":"https:\/\/doi.org\/10.1002\/jso.20357","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,18]]}}}